Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy
Introduction: It is acknowledged that any claim of efficacy of allergen immunotherapy must be done for each specific product, and this remains true also for venom immunotherapy (VIT). Thus, we evaluated the efficacy and safety of a specific tyrosine-adsorbed VIT for vespula spp. and honeybee in real...
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doaj-ec7f5c402ba748cbb1bae558132043fe2020-11-25T01:30:54ZengElsevierWorld Allergy Organization Journal1939-45512019-12-011212Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapyMaurizio Severino0Livio Simioni1Patrizia Bonadonna2Renato Cantone3Gabriele Cortellini4Stefano Crescioli5Anna D'Angelo6Luigi La Rosa7Donatella Macchia8Irene Martignago9Alessandro Massolo10Federico Reccardini11Diego Bagnasco12Giovanni Passalacqua13Anallergo S.p.A, Florence, ItalyAllergy Unit, Medicine Department, Ospedale S.Maria del Prato, AULSS 1 Dolomiti Regione Veneto, Feltre, ItalyAllergy Dept, Integrated University-Hospital of Verona, ItalyAllergy Unit, ASL, Novara, ItalyInternal Medicine and Rheumatology Dept, Rimini Hospital, Rimini, ItalyAllergy Unit, Bassano del Grappa, ItalyAllergy Unit, ASL, Novara, ItalyAllergy Unit, ASL, Novara, ItalyAllergy and Clinical Immunology Unit, Ospedale s. Giovanni di Dio, Florence, ItalyAllergy Unit, Medicine Department, Ospedale S.Maria del Prato, AULSS 1 Dolomiti Regione Veneto, Feltre, ItalyEthology Unit, Dept of Biology, University of Pisa, Italy; UMR CNRS 6249 Chrono-environnement, Université Bourgogne Franche-Comté, Besançon, France; Dept of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, CanadaAzienda Sanitaria Universitaria Integrata di Udine SOC Pneumologia - Fisiopatologia Respiratoria, Udine, ItalyAllergy and Respiratory Diesases, IRCCS Policlinico San Martino, University of Genoa, L.go R.Benzi 10, 16133, Genoa, ItalyAllergy and Respiratory Diesases, IRCCS Policlinico San Martino, University of Genoa, L.go R.Benzi 10, 16133, Genoa, Italy; Corresponding author. Allergy and Respiratory Diesases, IRCCS Policlinico San Martino, University of Genoa, L.go R.Benzi 10, 16133, Genoa, Italy.Introduction: It is acknowledged that any claim of efficacy of allergen immunotherapy must be done for each specific product, and this remains true also for venom immunotherapy (VIT). Thus, we evaluated the efficacy and safety of a specific tyrosine-adsorbed VIT for vespula spp. and honeybee in real-life. Methods: Consecutive patients diagnosed with hymenoptera allergy, and receiving VIT for either vespula or honeybee with a tyrosine-adsorbed preparation were observed to evaluate the grade of reaction (according to Muller) at the first field re-sting. A modified ultra-rush protocol was used. Results: A total of 247 patients (73 female) were observed (102 honeybee, group H, 145 vespula, group V). Seventy-five patients in group H had a re-sting, and 74/75 had a lower grade reaction at re-sting as compared to the pre-VIT reaction. Considering systemic reactions, protection was achieved in 89% of patients. In group V 118 patients were re-stung, and 76/118 patients with previous grade III-IV reaction had no more systemic reaction under VIT. Overall, considering systemic reactions, protection was achieved in 92% of subjects. Of note, in both groups there was a clear inverse correlation between the severity of pre-VIT and during VIT reactions. The duration of VIT at the time of re-sting did not affect the efficacy. The safety was overall good, with 18% ad 15.4% local reactions in groups H and V, respectively. Discussion: Modified extracts, including tyrosine-absorbed, have the aim of improving the safety of VIT still yet maintaining the efficacy. Field re-sting is the best way to assess the efficacy in real life. In this observational study we could confirm the protective efficacy of the tyrosine-adsorbed extract, with a good safety expecially in the build-up using a modified-rush protocol. Conclusion: The tyrosine-adsorbed VIT used herein is a viable and advantageous form of treatment for hymenoptera allergy. Keywords: Hymenoptera venom allergy, Venom immunotherapy, Tyrosine adsorbed, Efficacy, Safety, Systemic reaction, Field re-stinghttp://www.sciencedirect.com/science/article/pii/S1939455119312426 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maurizio Severino Livio Simioni Patrizia Bonadonna Renato Cantone Gabriele Cortellini Stefano Crescioli Anna D'Angelo Luigi La Rosa Donatella Macchia Irene Martignago Alessandro Massolo Federico Reccardini Diego Bagnasco Giovanni Passalacqua |
spellingShingle |
Maurizio Severino Livio Simioni Patrizia Bonadonna Renato Cantone Gabriele Cortellini Stefano Crescioli Anna D'Angelo Luigi La Rosa Donatella Macchia Irene Martignago Alessandro Massolo Federico Reccardini Diego Bagnasco Giovanni Passalacqua Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy World Allergy Organization Journal |
author_facet |
Maurizio Severino Livio Simioni Patrizia Bonadonna Renato Cantone Gabriele Cortellini Stefano Crescioli Anna D'Angelo Luigi La Rosa Donatella Macchia Irene Martignago Alessandro Massolo Federico Reccardini Diego Bagnasco Giovanni Passalacqua |
author_sort |
Maurizio Severino |
title |
Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy |
title_short |
Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy |
title_full |
Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy |
title_fullStr |
Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy |
title_full_unstemmed |
Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy |
title_sort |
efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy |
publisher |
Elsevier |
series |
World Allergy Organization Journal |
issn |
1939-4551 |
publishDate |
2019-12-01 |
description |
Introduction: It is acknowledged that any claim of efficacy of allergen immunotherapy must be done for each specific product, and this remains true also for venom immunotherapy (VIT). Thus, we evaluated the efficacy and safety of a specific tyrosine-adsorbed VIT for vespula spp. and honeybee in real-life. Methods: Consecutive patients diagnosed with hymenoptera allergy, and receiving VIT for either vespula or honeybee with a tyrosine-adsorbed preparation were observed to evaluate the grade of reaction (according to Muller) at the first field re-sting. A modified ultra-rush protocol was used. Results: A total of 247 patients (73 female) were observed (102 honeybee, group H, 145 vespula, group V). Seventy-five patients in group H had a re-sting, and 74/75 had a lower grade reaction at re-sting as compared to the pre-VIT reaction. Considering systemic reactions, protection was achieved in 89% of patients. In group V 118 patients were re-stung, and 76/118 patients with previous grade III-IV reaction had no more systemic reaction under VIT. Overall, considering systemic reactions, protection was achieved in 92% of subjects. Of note, in both groups there was a clear inverse correlation between the severity of pre-VIT and during VIT reactions. The duration of VIT at the time of re-sting did not affect the efficacy. The safety was overall good, with 18% ad 15.4% local reactions in groups H and V, respectively. Discussion: Modified extracts, including tyrosine-absorbed, have the aim of improving the safety of VIT still yet maintaining the efficacy. Field re-sting is the best way to assess the efficacy in real life. In this observational study we could confirm the protective efficacy of the tyrosine-adsorbed extract, with a good safety expecially in the build-up using a modified-rush protocol. Conclusion: The tyrosine-adsorbed VIT used herein is a viable and advantageous form of treatment for hymenoptera allergy. Keywords: Hymenoptera venom allergy, Venom immunotherapy, Tyrosine adsorbed, Efficacy, Safety, Systemic reaction, Field re-sting |
url |
http://www.sciencedirect.com/science/article/pii/S1939455119312426 |
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