Efficient Selection of Antibodies Reactive to Homologous Epitopes on Human and Mouse Hepatocyte Growth Factors by Next-Generation Sequencing-Based Analysis of the B Cell Repertoire

Efficient Selection of Antibodies Reactive to Homologous Epitopes on Human and Mouse Hepatocyte Growth Factors by Next-Generation Sequencing-Based Analysis of the B Cell Repertoire

: YYB-101 is a humanized rabbit anti-human hepatocyte growth factor (HGF)-neutralizing antibody currently in clinical trial. To test the effect of HGF neutralization with antibody on anti-cancer T cell immunity, we generated surrogate antibodies that are reactive to the mouse homologue of the epitop...

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Bibliographic Details
Main Authors: Soohyun Kim, Hyunho Lee, Jinsung Noh, Yonghee Lee, Haejun Han, Duck Kyun Yoo, Hyori Kim, Sunghoon Kwon, Junho Chung
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
next-generation sequencing
hepatocyte growth factor
B cell receptor
immune profiling
Online Access:http://www.mdpi.com/1422-0067/20/2/417

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