Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma

Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma

Glioblastoma multiforme (GBM) is a grade 4 and the most aggressive form of glioma, with a poor response to current treatments. The expression of microRNAs (miRNAs) is widely dysregulated in various cancers, including GBM. One of the overexpressed miRNAs in GBM is miR-21 which promotes proliferation,...

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Bibliographic Details
Main Authors: Hamideh Monfared, Yavar Jahangard, Maryam Nikkhah, Javad Mirnajafi-Zadeh, Seyed Javad Mowla
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
microRNA
miR-21
exosomes
sponge
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00782/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00782/full

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