Role of DSCAM in the Development of Neural Control of Movement and Locomotion
Locomotion results in an alternance of flexor and extensor muscles between left and right limbs generated by motoneurons that are controlled by the spinal interneuronal circuit. This spinal locomotor circuit is modulated by sensory afferents, which relay proprioceptive and cutaneous inputs that info...
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doaj-ec8fa2077dd643db827eff4fecb60b1c2021-08-26T13:51:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-01228511851110.3390/ijms22168511Role of DSCAM in the Development of Neural Control of Movement and LocomotionMaxime Lemieux0Louise Thiry1Olivier D. Laflamme2Frédéric Bretzner3Centre de Recherche du Centre Hospitalier Universitaire de Québec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Québec, QC G1V 4G2, CanadaCentre de Recherche du Centre Hospitalier Universitaire de Québec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Québec, QC G1V 4G2, CanadaCentre de Recherche du Centre Hospitalier Universitaire de Québec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Québec, QC G1V 4G2, CanadaCentre de Recherche du Centre Hospitalier Universitaire de Québec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Québec, QC G1V 4G2, CanadaLocomotion results in an alternance of flexor and extensor muscles between left and right limbs generated by motoneurons that are controlled by the spinal interneuronal circuit. This spinal locomotor circuit is modulated by sensory afferents, which relay proprioceptive and cutaneous inputs that inform the spatial position of limbs in space and potential contacts with our environment respectively, but also by supraspinal descending commands of the brain that allow us to navigate in complex environments, avoid obstacles, chase prey, or flee predators. Although signaling pathways are important in the establishment and maintenance of motor circuits, the role of DSCAM, a cell adherence molecule associated with Down syndrome, has only recently been investigated in the context of motor control and locomotion in the rodent. DSCAM is known to be involved in lamination and delamination, synaptic targeting, axonal guidance, dendritic and cell tiling, axonal fasciculation and branching, programmed cell death, and synaptogenesis, all of which can impact the establishment of motor circuits during development, but also their maintenance through adulthood. We discuss herein how DSCAM is important for proper motor coordination, especially for breathing and locomotion.https://www.mdpi.com/1422-0067/22/16/8511DSCAMmouse geneticsgaitposturespinal cordmotor cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maxime Lemieux Louise Thiry Olivier D. Laflamme Frédéric Bretzner |
spellingShingle |
Maxime Lemieux Louise Thiry Olivier D. Laflamme Frédéric Bretzner Role of DSCAM in the Development of Neural Control of Movement and Locomotion International Journal of Molecular Sciences DSCAM mouse genetics gait posture spinal cord motor cortex |
author_facet |
Maxime Lemieux Louise Thiry Olivier D. Laflamme Frédéric Bretzner |
author_sort |
Maxime Lemieux |
title |
Role of DSCAM in the Development of Neural Control of Movement and Locomotion |
title_short |
Role of DSCAM in the Development of Neural Control of Movement and Locomotion |
title_full |
Role of DSCAM in the Development of Neural Control of Movement and Locomotion |
title_fullStr |
Role of DSCAM in the Development of Neural Control of Movement and Locomotion |
title_full_unstemmed |
Role of DSCAM in the Development of Neural Control of Movement and Locomotion |
title_sort |
role of dscam in the development of neural control of movement and locomotion |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-08-01 |
description |
Locomotion results in an alternance of flexor and extensor muscles between left and right limbs generated by motoneurons that are controlled by the spinal interneuronal circuit. This spinal locomotor circuit is modulated by sensory afferents, which relay proprioceptive and cutaneous inputs that inform the spatial position of limbs in space and potential contacts with our environment respectively, but also by supraspinal descending commands of the brain that allow us to navigate in complex environments, avoid obstacles, chase prey, or flee predators. Although signaling pathways are important in the establishment and maintenance of motor circuits, the role of DSCAM, a cell adherence molecule associated with Down syndrome, has only recently been investigated in the context of motor control and locomotion in the rodent. DSCAM is known to be involved in lamination and delamination, synaptic targeting, axonal guidance, dendritic and cell tiling, axonal fasciculation and branching, programmed cell death, and synaptogenesis, all of which can impact the establishment of motor circuits during development, but also their maintenance through adulthood. We discuss herein how DSCAM is important for proper motor coordination, especially for breathing and locomotion. |
topic |
DSCAM mouse genetics gait posture spinal cord motor cortex |
url |
https://www.mdpi.com/1422-0067/22/16/8511 |
work_keys_str_mv |
AT maximelemieux roleofdscaminthedevelopmentofneuralcontrolofmovementandlocomotion AT louisethiry roleofdscaminthedevelopmentofneuralcontrolofmovementandlocomotion AT olivierdlaflamme roleofdscaminthedevelopmentofneuralcontrolofmovementandlocomotion AT fredericbretzner roleofdscaminthedevelopmentofneuralcontrolofmovementandlocomotion |
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1721192761401540608 |