Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort
Chinese herbal medicines (CHMs) have been successfully used in the treatment of infectious diseases, yet the effectiveness of CHMs for extensively drug-resistant enterobacteria (XDRE) infection remains unclear. Herein we developed a retrospective multicenter study including 766 patients with XDRE an...
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2017-01-01
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Online Access: | http://dx.doi.org/10.1155/2017/2897045 |
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doaj-ec91633358d148838ddc37a2aa232b902020-11-24T20:44:14ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/28970452897045Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective CohortYangping Cai0Qing Zhang1Yuefeng Fu2Li Li3Ning Zhao4Aiping Lu5Qingquan Liu6Miao Jiang7Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital, Beijing 100700, ChinaBeijing University of Chinese Medicine Affiliated Dongzhimen Hospital, Beijing 100700, ChinaBeijing University of Chinese Medicine Affiliated Dongzhimen Hospital, Beijing 100700, ChinaInstitute of Basic Research on Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Basic Research on Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong 999077, Hong KongBeijing Hospital of TCM, Beijing 100010, ChinaInstitute of Basic Research on Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaChinese herbal medicines (CHMs) have been successfully used in the treatment of infectious diseases, yet the effectiveness of CHMs for extensively drug-resistant enterobacteria (XDRE) infection remains unclear. Herein we developed a retrospective multicenter study including 766 patients with XDRE and nonfermentative bacteria (NFB) infection to investigate the effectiveness of CHMs combined with antibiotics in the treatment of XDRE infections in clinical daily practice in a cohort of patients and compared the regular antibiotics monotherapy. After 14-day treatment, the 547 patients accepted CHMs combined with antibiotics therapy indicating a more desirable effectiveness compared to the 219 patients treated with antibiotics monotherapy. The primary evaluation indexes included white blood cell count (WBC) and percentage of neutrophil (N%) in blood test. Secondary evaluation indexes consisted of body temperature, breath, heart rate, platelets, hemoglobin, red blood cell, albumin, creatinine, glucose, and 28-day survival rates. Briefly speaking, in our experience, CHMs combined with antibiotics therapy achieved more desirable effectiveness in treating XDRE infections compared with antibiotics monotherapy, and CHMs might be a potential huge resource in the field of XDRE infection management and enlighten the new antibiotics research and development. This trial is registered with ChiCTR-ORC-17011760.http://dx.doi.org/10.1155/2017/2897045 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yangping Cai Qing Zhang Yuefeng Fu Li Li Ning Zhao Aiping Lu Qingquan Liu Miao Jiang |
spellingShingle |
Yangping Cai Qing Zhang Yuefeng Fu Li Li Ning Zhao Aiping Lu Qingquan Liu Miao Jiang Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort BioMed Research International |
author_facet |
Yangping Cai Qing Zhang Yuefeng Fu Li Li Ning Zhao Aiping Lu Qingquan Liu Miao Jiang |
author_sort |
Yangping Cai |
title |
Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort |
title_short |
Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort |
title_full |
Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort |
title_fullStr |
Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort |
title_full_unstemmed |
Effectiveness of Chinese Herbal Medicine Combined with Antibiotics for Extensively Drug-Resistant Enterobacteria and Nonfermentative Bacteria Infection: Real-Life Experience in a Retrospective Cohort |
title_sort |
effectiveness of chinese herbal medicine combined with antibiotics for extensively drug-resistant enterobacteria and nonfermentative bacteria infection: real-life experience in a retrospective cohort |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
Chinese herbal medicines (CHMs) have been successfully used in the treatment of infectious diseases, yet the effectiveness of CHMs for extensively drug-resistant enterobacteria (XDRE) infection remains unclear. Herein we developed a retrospective multicenter study including 766 patients with XDRE and nonfermentative bacteria (NFB) infection to investigate the effectiveness of CHMs combined with antibiotics in the treatment of XDRE infections in clinical daily practice in a cohort of patients and compared the regular antibiotics monotherapy. After 14-day treatment, the 547 patients accepted CHMs combined with antibiotics therapy indicating a more desirable effectiveness compared to the 219 patients treated with antibiotics monotherapy. The primary evaluation indexes included white blood cell count (WBC) and percentage of neutrophil (N%) in blood test. Secondary evaluation indexes consisted of body temperature, breath, heart rate, platelets, hemoglobin, red blood cell, albumin, creatinine, glucose, and 28-day survival rates. Briefly speaking, in our experience, CHMs combined with antibiotics therapy achieved more desirable effectiveness in treating XDRE infections compared with antibiotics monotherapy, and CHMs might be a potential huge resource in the field of XDRE infection management and enlighten the new antibiotics research and development. This trial is registered with ChiCTR-ORC-17011760. |
url |
http://dx.doi.org/10.1155/2017/2897045 |
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