Methotrexate Restores CD73 Expression on Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis Patients and May Contribute to Its Anti-Inflammatory Effect through Ado Production

Methotrexate Restores CD73 Expression on Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis Patients and May Contribute to Its Anti-Inflammatory Effect through Ado Production

Objectives: Th1.17 are highly polyfunctional, potentially harmful CD4<sup>+</sup> effector T cells (Teff) through IFN-&#947; and IL-17A coproduction. Th1.17 take part in the pathophysiology of rheumatoid arthritis (RA) and psoriatic arthritis (PsA), in which their hyper activation re...

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Bibliographic Details
Main Authors: Marion Bossennec, Céline Rodriguez, Margaux Hubert, Anthony Di-Roio, Christelle Machon, Jérôme Guitton, Priscilla Battiston-Montagne, Mathilde Couturier, Hubert Marotte, Christophe Caux, Fabienne Coury, Christine Ménétrier-Caux
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Journal of Clinical Medicine
Subjects:
th1.17
il-17a
ifn-γ, cd73
adenosine
rheumatoid arthritis
psoriatic arthritis
methotrexate
regulation
Online Access:https://www.mdpi.com/2077-0383/8/11/1859

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