| Summary: | Background: The pathophysiology of angina-like symptoms in myocarditis is still unclear. Perivascular fat attenuation index (pFAI) by coronary computed tomography angiography (CCTA) is a non-invasive marker of coronary inflammation (CI) in atherosclerosis. We explored the presence of CI in clinically suspected myocarditis with infarct-like presentation. Methods: We retrospectively included 15 consecutive patients (67% male, age 30 ± 10 years) with clinically suspected infarct-like myocarditis who underwent CCTA to rule out coronary artery disease. Right coronary artery (RCA) pFAI mean value was compared with that of healthy volunteers. Results: Mean RCA pFAI value was −92.8 ± 8.4 HU, similar to that of healthy volunteers (−95.2 ± 6.0, <i>p</i> = 0.8). We found no correlation between RCA pFAI mean values and peak Troponin I (r = −0.43, <i>p</i> = 0.11) and C-reactive protein at diagnosis (r = −0.25, <i>p</i> = 0.42). Patients with higher pFAI values showed higher biventricular end-systolic volumes (ESV) (<i>p</i> = 0.038 for left and <i>p</i> = 0.024 for right ventricle) and lower right ventricular ejection fraction (RVEF) (<i>p</i> = 0.038) on cardiovascular magnetic resonance. Conclusions: In clinically suspected myocarditis with infarct-like presentation, RCA pFAI values are lower than those validated in atherosclerosis. The correlation between higher pFAI values, higher biventricular ESV and lower RVEF, may suggest a role of pFAI in predicting non-atherosclerotic CI (i.e., infective/immune-mediated “endothelialitis”).
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