TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-dependent transgene repression and H3K9me3 deposition o...

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Main Authors:	Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18761-6

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spelling	doaj-ec9909b7b0774e2691625135a2850ac12021-10-03T11:52:04ZengNature Publishing GroupNature Communications2041-17232020-10-0111111610.1038/s41467-020-18761-6TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon controlChristopher H. Douse0Iva A. Tchasovnikarova1Richard T. Timms2Anna V. Protasio3Marta Seczynska4Daniil M. Prigozhin5Anna Albecka6Jane Wagstaff7James C. Williamson8Stefan M. V. Freund9Paul J. Lehner10Yorgo Modis11Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge Biomedical CampusCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical MedicineCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical MedicineCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical MedicineCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical MedicineMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge Biomedical CampusMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge Biomedical CampusStructural Studies Division, MRC Laboratory of Molecular BiologyCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical MedicineStructural Studies Division, MRC Laboratory of Molecular BiologyCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge School of Clinical MedicineMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge Biomedical CampusThe HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-dependent transgene repression and H3K9me3 deposition over targets genome wide.https://doi.org/10.1038/s41467-020-18761-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christopher H. Douse Iva A. Tchasovnikarova Richard T. Timms Anna V. Protasio Marta Seczynska Daniil M. Prigozhin Anna Albecka Jane Wagstaff James C. Williamson Stefan M. V. Freund Paul J. Lehner Yorgo Modis
spellingShingle	Christopher H. Douse Iva A. Tchasovnikarova Richard T. Timms Anna V. Protasio Marta Seczynska Daniil M. Prigozhin Anna Albecka Jane Wagstaff James C. Williamson Stefan M. V. Freund Paul J. Lehner Yorgo Modis TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control Nature Communications
author_facet	Christopher H. Douse Iva A. Tchasovnikarova Richard T. Timms Anna V. Protasio Marta Seczynska Daniil M. Prigozhin Anna Albecka Jane Wagstaff James C. Williamson Stefan M. V. Freund Paul J. Lehner Yorgo Modis
author_sort	Christopher H. Douse
title	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_short	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_full	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_fullStr	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_full_unstemmed	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_sort	tasor is a pseudo-parp that directs hush complex assembly and epigenetic transposon control
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-dependent transgene repression and H3K9me3 deposition over targets genome wide.
url	https://doi.org/10.1038/s41467-020-18761-6
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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

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