The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus

The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus

The paper presents data on positive and negative metabolic memory phenomena in patients with type 1 and type 2 diabetes mellitus (DM) as exemplified by the long-term randomized trials DCCT, UKPDS, ACCORD, VADT, and ADVANCE. It discusses the role of metabolic memory in predicting a risk for vascular...

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Bibliographic Details
Main Authors: I I Dedov, M V Shestakova
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2015-10-01
Series:Терапевтический архив
Subjects:
diabetes mellitus
positive and negative metabolic memory
micro- and macroangiopathies
oxidative stress
epigenetics
Online Access:https://ter-arkhiv.ru/0040-3660/article/view/31799
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spelling doaj-ec9d8092adac4b7dac2861f879d883be2020-11-25T03:04:45Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-10-01871041028815The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitusI I DedovM V ShestakovaThe paper presents data on positive and negative metabolic memory phenomena in patients with type 1 and type 2 diabetes mellitus (DM) as exemplified by the long-term randomized trials DCCT, UKPDS, ACCORD, VADT, and ADVANCE. It discusses the role of metabolic memory in predicting a risk for vascular complications in DM. Ideas on the mechanisms of this phenomenon, which are based on the activation of oxidative stress, the production of irreversible glycation products, and epigenetic disorders, are given.https://ter-arkhiv.ru/0040-3660/article/view/31799diabetes mellituspositive and negative metabolic memorymicro- and macroangiopathiesoxidative stressepigenetics
collection DOAJ
language Russian
format Article
sources DOAJ
author I I Dedov
M V Shestakova
spellingShingle I I Dedov
M V Shestakova
The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus
Терапевтический архив
diabetes mellitus
positive and negative metabolic memory
micro- and macroangiopathies
oxidative stress
epigenetics
author_facet I I Dedov
M V Shestakova
author_sort I I Dedov
title The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus
title_short The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus
title_full The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus
title_fullStr The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus
title_full_unstemmed The metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus
title_sort metabolic memory phenomenon in predicting a risk for vascular complications in diabetes mellitus
publisher "Consilium Medicum" Publishing house
series Терапевтический архив
issn 0040-3660
2309-5342
publishDate 2015-10-01
description The paper presents data on positive and negative metabolic memory phenomena in patients with type 1 and type 2 diabetes mellitus (DM) as exemplified by the long-term randomized trials DCCT, UKPDS, ACCORD, VADT, and ADVANCE. It discusses the role of metabolic memory in predicting a risk for vascular complications in DM. Ideas on the mechanisms of this phenomenon, which are based on the activation of oxidative stress, the production of irreversible glycation products, and epigenetic disorders, are given.
topic diabetes mellitus
positive and negative metabolic memory
micro- and macroangiopathies
oxidative stress
epigenetics
url https://ter-arkhiv.ru/0040-3660/article/view/31799
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AT mvshestakova themetabolicmemoryphenomenoninpredictingariskforvascularcomplicationsindiabetesmellitus
AT iidedov metabolicmemoryphenomenoninpredictingariskforvascularcomplicationsindiabetesmellitus
AT mvshestakova metabolicmemoryphenomenoninpredictingariskforvascularcomplicationsindiabetesmellitus
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