Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder
Recent advances in robust and reliable methods of MRI-derived cerebellar lobule parcellation volumetry present the opportunity to assess effects of Alcohol Use Disorder (AUD) on selective cerebellar lobules and relations with indices of nutrition and motor functions. In pursuit of this opportunity,...
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doaj-eca08d610f734abf842f0aaa3c4ba0172020-11-25T02:16:41ZengElsevierNeuroImage: Clinical2213-15822019-01-0124Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use DisorderEdith V. Sullivan0Natalie M. Zahr1Manojkumar Saranathan2Kilian M. Pohl3Adolf Pfefferbaum4Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States of America; Corresponding author at: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine (MC5723), 401 Quarry Road, Stanford, CA 94305-5723, United States of America.Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States of America; Center for Health Sciences, SRI International, Menlo Park, CA, United States of AmericaDepartment of Medical Imaging, University of Arizona, Tucson, AZ, United States of AmericaDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States of America; Center for Health Sciences, SRI International, Menlo Park, CA, United States of AmericaDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States of America; Center for Health Sciences, SRI International, Menlo Park, CA, United States of AmericaRecent advances in robust and reliable methods of MRI-derived cerebellar lobule parcellation volumetry present the opportunity to assess effects of Alcohol Use Disorder (AUD) on selective cerebellar lobules and relations with indices of nutrition and motor functions. In pursuit of this opportunity, we analyzed high-resolution MRI data acquired in 24 individuals with AUD and 20 age- and sex-matched controls with a 32-channel head coil using three different atlases: the online automated analysis pipeline volBrain Ceres, SUIT, and the Johns Hopkins atlas. Participants had also completed gait and balance examination and hematological analysis of nutritional and liver status, enabling testing of functional meaningfulness of each cerebellar parcellation scheme. Compared with controls, each quantification approach yielded similar patterns of group differences in regional volumes: All three approaches identified AUD-related deficits in total tissue and total gray matter, but only Ceres identified a total white matter volume deficit. Convergent volume differences occurred in lobules I-V, Crus I, VIIIB, and IX. Coefficients of variation (CVs) were <20% for 46 of 56 regions measured and in general were graded: Ceres<SUIT<Hopkins. The most robust correlations were identified between poorer stability in balancing on one leg and smaller lobule VI and Crus I volumes from the Ceres atlas. Lower values of two essential vitamins—thiamine (vitamin B1) and serum folate (vitamin B9)—along with lower red blood cell count, which are dependent on adequate levels of B vitamins, correlated with smaller gray matter volumes of lobule VI and Crus I. Higher γ-glutamyl transferase (GGT) levels, possibly reflecting compromised liver function, correlated with smaller volumes of lobules VI and X. These initial results based on high resolution data produced with clinically practical imaging procedures hold promise for expanding our knowledge about the relevance of focal cerebellar morphology in AUD and other neuropsychiatric conditions. Keywords: Cerebellum, Alcohol, MRI, Cognition, Balance, Nutritionhttp://www.sciencedirect.com/science/article/pii/S2213158219303249 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Edith V. Sullivan Natalie M. Zahr Manojkumar Saranathan Kilian M. Pohl Adolf Pfefferbaum |
spellingShingle |
Edith V. Sullivan Natalie M. Zahr Manojkumar Saranathan Kilian M. Pohl Adolf Pfefferbaum Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder NeuroImage: Clinical |
author_facet |
Edith V. Sullivan Natalie M. Zahr Manojkumar Saranathan Kilian M. Pohl Adolf Pfefferbaum |
author_sort |
Edith V. Sullivan |
title |
Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder |
title_short |
Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder |
title_full |
Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder |
title_fullStr |
Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder |
title_full_unstemmed |
Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder |
title_sort |
convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in alcohol use disorder |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2019-01-01 |
description |
Recent advances in robust and reliable methods of MRI-derived cerebellar lobule parcellation volumetry present the opportunity to assess effects of Alcohol Use Disorder (AUD) on selective cerebellar lobules and relations with indices of nutrition and motor functions. In pursuit of this opportunity, we analyzed high-resolution MRI data acquired in 24 individuals with AUD and 20 age- and sex-matched controls with a 32-channel head coil using three different atlases: the online automated analysis pipeline volBrain Ceres, SUIT, and the Johns Hopkins atlas. Participants had also completed gait and balance examination and hematological analysis of nutritional and liver status, enabling testing of functional meaningfulness of each cerebellar parcellation scheme. Compared with controls, each quantification approach yielded similar patterns of group differences in regional volumes: All three approaches identified AUD-related deficits in total tissue and total gray matter, but only Ceres identified a total white matter volume deficit. Convergent volume differences occurred in lobules I-V, Crus I, VIIIB, and IX. Coefficients of variation (CVs) were <20% for 46 of 56 regions measured and in general were graded: Ceres<SUIT<Hopkins. The most robust correlations were identified between poorer stability in balancing on one leg and smaller lobule VI and Crus I volumes from the Ceres atlas. Lower values of two essential vitamins—thiamine (vitamin B1) and serum folate (vitamin B9)—along with lower red blood cell count, which are dependent on adequate levels of B vitamins, correlated with smaller gray matter volumes of lobule VI and Crus I. Higher γ-glutamyl transferase (GGT) levels, possibly reflecting compromised liver function, correlated with smaller volumes of lobules VI and X. These initial results based on high resolution data produced with clinically practical imaging procedures hold promise for expanding our knowledge about the relevance of focal cerebellar morphology in AUD and other neuropsychiatric conditions. Keywords: Cerebellum, Alcohol, MRI, Cognition, Balance, Nutrition |
url |
http://www.sciencedirect.com/science/article/pii/S2213158219303249 |
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