Nodular regenerative hyperplasia of the liver and cutaneous T-cell lymphoma: an unreported association

• Main Authors: Verónica Ciria-Bru, Álvaro Giráldez-Gallego, Diego Pascual-Vaca-Gómez, Teresa Zulueta-Dorado, Verónica Nacarino-Mejías
• Format: Article
• Language: English
• Published: Aran Ediciones 2014-04-01
• Series: Revista Espanola de Enfermedades Digestivas
• Subjects: Hiperplasia nodular regenerativa; Linfoma cutáneo de células T; Vitamina A; Micosis fungoide
• Online Access: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082014000400010&lng=en&tlng=en

Nodular regenerative hyperplasia of the liver -a type of non-cirrhotic portal hypertension- is a rare condition of unknown etiopathogenesis that has been associated with multiple disorders, including diverse types of hematologic disease. We report the case of a 36-year-old female patient diagnosed with cutaneous T-cell lymphoma of the mycosis fungoides variety, staged as T2N0M0B0, where a transjugular liver biopsy demonstrated the presence of nodular regenerative hyperplasia with a hepatic venous pressure gradient of 15 mm Hg. The study was triggered by the incidental radiologic finding of hepatomegaly with indirect evidence of portal hypertension. We are not aware of any previous reports on the association of nodular regenerative hyperplasia with mycosis fungoides in the medical literature.