SYNTHESES AND ANTIOXIDANT ACTIVITIES OF SOME HYDROXY DIMETHOXY CHALCONE DERIVATIVES

• Main Authors: Elfi Susanti VH, Sabirin Matsjeh, Mustofa, Tri Redjeki, Tutik Dwi Wahyuningsih
• Format: Article
• Language: English
• Published: Universitas Gadjah Mada 2014-01-01
• Series: Indonesian Journal of Pharmacy
• Subjects: hydroxy dimethoxy chalcone; Claisen-Schmidt condensation; grinding; DPPH method
• Online Access: http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/14

Four (4) hydroxy dimethoxy chalcones derivatives were synthesized by Claisen-Schmidt condensation of hydroxyacetophenone with 3,4-dimethoxybenzaldehyde using conventional method and grinding technique. The synthesized compounds were characterized by spectroscopy (IR, 1H-NMR and 13C-NMR). Synthesis of the hydroxy dimethoxy chalcone using grinding method is better than the conventional method. The synthesis using grinding method require a low concentration base, shorter reaction (15min) and higher yield (70-84%). The antioxidant activity of the compounds was determined by DPPH method, showed that 2',5'-dihydroxy-3,4-dimethoxy chalcone have the highest antioxidant activity.