Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass

Porous composite scaffold using an alginate and bioactive glass ICIE16M was synthesized by a simple freeze-drying technique. The scaffold was characterized using compression testing, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), X-r...

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Main Authors:	Jonathan Hatton, Graham Roy Davis, Abdel-Hamid I. Mourad, Nizamudeen Cherupurakal, Robert G. Hill, Sahar Mohsin
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	Journal of Functional Biomaterials
Subjects:	bone scaffolds alginate bioactive glass freeze-drying porous strontium
Online Access:	http://www.mdpi.com/2079-4983/10/1/15

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spelling	doaj-ecba4e41514b4b33a3b3d73dc4e375e62020-11-24T21:33:23ZengMDPI AGJournal of Functional Biomaterials2079-49832019-03-011011510.3390/jfb10010015jfb10010015Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive GlassJonathan Hatton0Graham Roy Davis1Abdel-Hamid I. Mourad2Nizamudeen Cherupurakal3Robert G. Hill4Sahar Mohsin5Dental Physical Sciences Unit, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UKDental Physical Sciences Unit, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UKDepartment of Mechanical Engineering, College of Engineering, UAEU Al Ain, 15551, UAEDepartment of Mechanical Engineering, College of Engineering, UAEU Al Ain, 15551, UAEDental Physical Sciences Unit, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UKDental Physical Sciences Unit, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UKPorous composite scaffold using an alginate and bioactive glass ICIE16M was synthesized by a simple freeze-drying technique. The scaffold was characterized using compression testing, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), X-ray microtomography (XMT) and scanning electron microscopy (SEM). The bioactivity of the scaffold was evaluated by its ability to form apatite on its surface in simulated body fluid (SBF). The data collected showed evidence that the novel material produced had an appropriate pore size for osteoconduction, with an average pore size of 110 µm and maximum pore size of 309 µm. Statistical analysis confirmed that the glass filler significantly (P < 0.05) increased the collapse yield of the scaffolds compared with pure alginate scaffolds. The ICIE16M glass had an amorphous structure, favorable for bioactivity.http://www.mdpi.com/2079-4983/10/1/15bone scaffoldsalginatebioactive glassfreeze-dryingporousstrontium
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jonathan Hatton Graham Roy Davis Abdel-Hamid I. Mourad Nizamudeen Cherupurakal Robert G. Hill Sahar Mohsin
spellingShingle	Jonathan Hatton Graham Roy Davis Abdel-Hamid I. Mourad Nizamudeen Cherupurakal Robert G. Hill Sahar Mohsin Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass Journal of Functional Biomaterials bone scaffolds alginate bioactive glass freeze-drying porous strontium
author_facet	Jonathan Hatton Graham Roy Davis Abdel-Hamid I. Mourad Nizamudeen Cherupurakal Robert G. Hill Sahar Mohsin
author_sort	Jonathan Hatton
title	Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass
title_short	Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass
title_full	Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass
title_fullStr	Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass
title_full_unstemmed	Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass
title_sort	fabrication of porous bone scaffolds using alginate and bioactive glass
publisher	MDPI AG
series	Journal of Functional Biomaterials
issn	2079-4983
publishDate	2019-03-01
description	Porous composite scaffold using an alginate and bioactive glass ICIE16M was synthesized by a simple freeze-drying technique. The scaffold was characterized using compression testing, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), X-ray microtomography (XMT) and scanning electron microscopy (SEM). The bioactivity of the scaffold was evaluated by its ability to form apatite on its surface in simulated body fluid (SBF). The data collected showed evidence that the novel material produced had an appropriate pore size for osteoconduction, with an average pore size of 110 µm and maximum pore size of 309 µm. Statistical analysis confirmed that the glass filler significantly (P < 0.05) increased the collapse yield of the scaffolds compared with pure alginate scaffolds. The ICIE16M glass had an amorphous structure, favorable for bioactivity.
topic	bone scaffolds alginate bioactive glass freeze-drying porous strontium
url	http://www.mdpi.com/2079-4983/10/1/15
work_keys_str_mv	AT jonathanhatton fabricationofporousbonescaffoldsusingalginateandbioactiveglass AT grahamroydavis fabricationofporousbonescaffoldsusingalginateandbioactiveglass AT abdelhamidimourad fabricationofporousbonescaffoldsusingalginateandbioactiveglass AT nizamudeencherupurakal fabricationofporousbonescaffoldsusingalginateandbioactiveglass AT robertghill fabricationofporousbonescaffoldsusingalginateandbioactiveglass AT saharmohsin fabricationofporousbonescaffoldsusingalginateandbioactiveglass
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Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass

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