Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
<h4>Background</h4>The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. The prediction has been that reducing Abeta production...
Main Authors: | Joanna L Jankowsky, Hilda H Slunt, Victoria Gonzales, Alena V Savonenko, Jason C Wen, Nancy A Jenkins, Neal G Copeland, Linda H Younkin, Henry A Lester, Steven G Younkin, David R Borchelt |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2005-12-01
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Series: | PLoS Medicine |
Online Access: | https://doi.org/10.1371/journal.pmed.0020355 |
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