The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.
In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4-induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4, the number of se...
Main Authors: | Hideyuki Ogiso, Hiroyasu Ito, Tatsuya Ando, Yuko Arioka, Ayumu Kanbe, Kazuki Ando, Tetsuya Ishikawa, Kuniaki Saito, Akira Hara, Hisataka Moriwaki, Masahito Shimizu, Mitsuru Seishima |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5012673?pdf=render |
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