Immunohistochemical evidence for the presence of a vasoactive intestinal peptide, neuropeptide Y and substance P in rat adrenal medulla after heat stress

• Main Authors: Petrović-Kosanović Dragana, Koko Vesna
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2012-01-01
• Series: Archives of Biological Sciences
• Subjects: Rat; adrenal medulla; heat stress; vasoactive intestinal peptide; neuropeptide Y and substance P
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2012/0354-46641201007P.pdf

Immunohistochemistry revealed the presence of VIP-, NPY- and SP-immunoreactivity in the rat adrenal medulla. VIP- and NPY-immunoreactivity was detected in chromaffin and ganglion cells and in nerve fibers, but SP-immunoreactivity was found only in chromaffin cells. After acute heat stress, VIP- and NPY- immunoreactivities in cells and nerve fibers were reduced, probably as a result of the release of these peptides with catecholamines. The absence of SP-immunoreactive ganglion cells in the adrenal medulla suggests that the SP-immunoreactive nerve fibers are extrinsic in origin.