Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women

Breast cancer is the most commonly diagnosed cancer and remains one of the main reasons of cancer-related mortality in women worldwide. KRAS variant rs61764370 (T>G) is associated with an increased risk of occurrence of many cancers, Here The case-control study was accomplished on 135 women incl...

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Main Author: Al-Haddad et al.
Format: Article
Language:Arabic
Published: College of Science for Women, University of Baghdad 2020-05-01
Series:Baghdad Science Journal
Subjects:
Online Access:http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3573
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spelling doaj-ecd3dcb4a7544d3bb0af11afe818fdbc2020-11-25T03:26:41ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862020-05-0117210.21123/bsj.2020.17.2.0426Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi WomenAl-Haddad et al.0Medical molecular genetic/ Biotechnology Department/Al-Nahrain university Breast cancer is the most commonly diagnosed cancer and remains one of the main reasons of cancer-related mortality in women worldwide. KRAS variant rs61764370 (T>G) is associated with an increased risk of occurrence of many cancers, Here The case-control study was accomplished on 135 women including 45 women with breast cancer patients, 45 women with benign breast lesions and 45 healthy women to analyze the association of KRAS variant rs (61764370 T>G) with breast cancer. LCS 6 variant in KRAS gene was amplified by using specific primers, then genotype was detected after sequencing the PCR products. The results showed that the genotype and allele frequency of TT and GT allele of  KRAS gene were statistically non-significant (p< 0.01) among breast cancer patients and breast benign lesions compared with healthy controls in Iraqi women. http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3573Breast benign lesions, Breast cancer, KRAS, rs 61764370
collection DOAJ
language Arabic
format Article
sources DOAJ
author Al-Haddad et al.
spellingShingle Al-Haddad et al.
Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women
Baghdad Science Journal
Breast benign lesions, Breast cancer, KRAS, rs 61764370
author_facet Al-Haddad et al.
author_sort Al-Haddad et al.
title Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women
title_short Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women
title_full Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women
title_fullStr Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women
title_full_unstemmed Lack of Association between LCS6 Variant in KRAS Gene with the Occurrence of Breast Tumors in Iraqi Women
title_sort lack of association between lcs6 variant in kras gene with the occurrence of breast tumors in iraqi women
publisher College of Science for Women, University of Baghdad
series Baghdad Science Journal
issn 2078-8665
2411-7986
publishDate 2020-05-01
description Breast cancer is the most commonly diagnosed cancer and remains one of the main reasons of cancer-related mortality in women worldwide. KRAS variant rs61764370 (T>G) is associated with an increased risk of occurrence of many cancers, Here The case-control study was accomplished on 135 women including 45 women with breast cancer patients, 45 women with benign breast lesions and 45 healthy women to analyze the association of KRAS variant rs (61764370 T>G) with breast cancer. LCS 6 variant in KRAS gene was amplified by using specific primers, then genotype was detected after sequencing the PCR products. The results showed that the genotype and allele frequency of TT and GT allele of  KRAS gene were statistically non-significant (p< 0.01) among breast cancer patients and breast benign lesions compared with healthy controls in Iraqi women.
topic Breast benign lesions, Breast cancer, KRAS, rs 61764370
url http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3573
work_keys_str_mv AT alhaddadetal lackofassociationbetweenlcs6variantinkrasgenewiththeoccurrenceofbreasttumorsiniraqiwomen
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