Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension

Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease de...

Full description

Bibliographic Details
Main Authors: Ruslan Rafikov, Joel James, Nolan McClain, Stevan P. Tofovic, Olga Rafikova
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Antioxidants
Subjects:
pulmonary hypertension
gender difference
redox homeostasis
oxidation
antioxidants
Online Access:https://www.mdpi.com/2076-3921/8/5/135
Description
Summary:Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology.
ISSN:2076-3921

Similar Items