Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013
Background: The purpose of this study was to determine the species distribution and to monitor the antifungal susceptibility profiles of clinical Candida isolates collected in China from 2009 to 2013. Methods: The antifungal susceptibilities of 952 Candida isolates were tested. Results: Candida alb...
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doaj-ecd7a68b77724020b9d6f66ac11b6ab02020-11-24T22:40:13ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-04-0133C1410.1016/j.ijid.2014.12.033Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013Lei Zhang0Shusheng Zhou1Aijun Pan2Jiabin Li3Bao Liu4Department of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, ChinaDepartment of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, ChinaDepartment of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, ChinaDepartment of Infectious Disease, the First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Critical Care Medicine, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China Background: The purpose of this study was to determine the species distribution and to monitor the antifungal susceptibility profiles of clinical Candida isolates collected in China from 2009 to 2013. Methods: The antifungal susceptibilities of 952 Candida isolates were tested. Results: Candida albicans was the most common species, accounting for 65.7% of the total isolates. The most frequently isolated non-albicans Candida species in this study was Candida glabrata (193, 20.3%). Nearly 7.6%, 3.2%, 1.8%, and 1.1% of the 952 isolates exhibited decreased susceptibility to fluconazole, voriconazole, itraconazole, and flucytosine, respectively. Moreover, seven C. albicans and one Candida krusei had an amphotericin B minimum inhibitory concentration (MIC) of 2 μg/ml. Conclusions: The distribution of species and the prevalence of antifungal resistance in Candida isolates varied among different areas in China. Continuous monitoring of resistance patterns is necessary to control the spread of resistance in clinical isolates of Candida species. http://www.sciencedirect.com/science/article/pii/S1201971214017512Candida speciesAzolesFluconazoleAntifungal susceptibility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Zhang Shusheng Zhou Aijun Pan Jiabin Li Bao Liu |
spellingShingle |
Lei Zhang Shusheng Zhou Aijun Pan Jiabin Li Bao Liu Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013 International Journal of Infectious Diseases Candida species Azoles Fluconazole Antifungal susceptibility |
author_facet |
Lei Zhang Shusheng Zhou Aijun Pan Jiabin Li Bao Liu |
author_sort |
Lei Zhang |
title |
Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013 |
title_short |
Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013 |
title_full |
Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013 |
title_fullStr |
Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013 |
title_full_unstemmed |
Surveillance of antifungal susceptibilities in clinical isolates of Candida species at 36 hospitals in China from 2009 to 2013 |
title_sort |
surveillance of antifungal susceptibilities in clinical isolates of candida species at 36 hospitals in china from 2009 to 2013 |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 1878-3511 |
publishDate |
2015-04-01 |
description |
Background: The purpose of this study was to determine the species distribution and to monitor the antifungal susceptibility profiles of clinical Candida isolates collected in China from 2009 to 2013.
Methods: The antifungal susceptibilities of 952 Candida isolates were tested.
Results: Candida albicans was the most common species, accounting for 65.7% of the total isolates. The most frequently isolated non-albicans Candida species in this study was Candida glabrata (193, 20.3%). Nearly 7.6%, 3.2%, 1.8%, and 1.1% of the 952 isolates exhibited decreased susceptibility to fluconazole, voriconazole, itraconazole, and flucytosine, respectively. Moreover, seven C. albicans and one Candida krusei had an amphotericin B minimum inhibitory concentration (MIC) of 2 μg/ml.
Conclusions: The distribution of species and the prevalence of antifungal resistance in Candida isolates varied among different areas in China. Continuous monitoring of resistance patterns is necessary to control the spread of resistance in clinical isolates of Candida species.
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topic |
Candida species Azoles Fluconazole Antifungal susceptibility |
url |
http://www.sciencedirect.com/science/article/pii/S1201971214017512 |
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