Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits
Purpose. This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits. Materials and Methods. Bovine bone mineral was grafted on the sinuses of 20 female New Zealand w...
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Online Access: | http://dx.doi.org/10.1155/2017/6087676 |
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doaj-ece8aa8646a24e44a6accbaf2c8183ed2020-11-24T21:05:35ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/60876766087676Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy RabbitsJisun Huh0Ui-Won Jung1Kyeong-Mee Park2Hyun Sil Kim3Kee-Deog Kim4Wonse Park5Department of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of KoreaDepartment of Periodontology, College of Dentistry, Yonsei University, Seoul, Republic of KoreaDepartment of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of KoreaDepartment of Oral Pathology, College of Dentistry, Yonsei University, Seoul, Republic of KoreaDepartment of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of KoreaDepartment of Advanced General Dentistry, College of Dentistry, Yonsei University, Seoul, Republic of KoreaPurpose. This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits. Materials and Methods. Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits. The animals were randomly divided into two groups, PTH (n=10) or saline (n=10), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks. Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively. The dosage of PTH was 10 μg/kg/day. Radiographic and histomorphometric analyses were performed. Result. The new bone area (NBA) did not differ significantly between the PTH and saline groups. The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks. The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups. Conclusion. Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing.http://dx.doi.org/10.1155/2017/6087676 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jisun Huh Ui-Won Jung Kyeong-Mee Park Hyun Sil Kim Kee-Deog Kim Wonse Park |
spellingShingle |
Jisun Huh Ui-Won Jung Kyeong-Mee Park Hyun Sil Kim Kee-Deog Kim Wonse Park Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits BioMed Research International |
author_facet |
Jisun Huh Ui-Won Jung Kyeong-Mee Park Hyun Sil Kim Kee-Deog Kim Wonse Park |
author_sort |
Jisun Huh |
title |
Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits |
title_short |
Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits |
title_full |
Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits |
title_fullStr |
Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits |
title_full_unstemmed |
Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits |
title_sort |
parathyroid hormone (1-34) might not improve early bone healing after sinus augmentation in healthy rabbits |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
Purpose. This study evaluated the effect of administering intermittent parathyroid hormone [PTH (1-34), henceforth PTH] on the early-stage bone healing of maxillary sinus augmentation in healthy rabbits. Materials and Methods. Bovine bone mineral was grafted on the sinuses of 20 female New Zealand white rabbits. The animals were randomly divided into two groups, PTH (n=10) or saline (n=10), in which either PTH or saline was injected subcutaneously 5 days a week for 2 weeks. Half of the animals in each group were killed at 2 weeks postoperatively and the other half were killed at 4 weeks postoperatively. The dosage of PTH was 10 μg/kg/day. Radiographic and histomorphometric analyses were performed. Result. The new bone area (NBA) did not differ significantly between the PTH and saline groups. The NBA in the PTH group in the total augmented area and in the demarcated window, center, and Schneiderian membrane regions increased significantly from 2 to 4 weeks. The number of osteoclasts decreased significantly from 2 to 4 weeks in both groups, with no difference between the two groups. Conclusion. Intermittent PTH might not stimulate new bone formation in healthy rabbits during the first 4 weeks of healing. |
url |
http://dx.doi.org/10.1155/2017/6087676 |
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