TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis

TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis

Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid prog...

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Main Authors: Xue-Yan Chen, Bing-Xi Yan, Xiao-Yong Man
Format: Article
Language:English
Published: SAGE Publishing 2020-05-01
Series:Therapeutic Advances in Respiratory Disease
Online Access:https://doi.org/10.1177/1753466620926800
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spelling doaj-ecf43089a2df49f0a45f4efb707a5d472020-11-25T02:42:13ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46662020-05-011410.1177/1753466620926800TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysisXue-Yan ChenBing-Xi YanXiao-Yong ManIncreased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section.https://doi.org/10.1177/1753466620926800
collection DOAJ
language English
format Article
sources DOAJ
author Xue-Yan Chen
Bing-Xi Yan
Xiao-Yong Man
spellingShingle Xue-Yan Chen
Bing-Xi Yan
Xiao-Yong Man
TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
Therapeutic Advances in Respiratory Disease
author_facet Xue-Yan Chen
Bing-Xi Yan
Xiao-Yong Man
author_sort Xue-Yan Chen
title TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_short TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_full TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_fullStr TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_full_unstemmed TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
title_sort tnfα inhibitor may be effective for severe covid-19: learning from toxic epidermal necrolysis
publisher SAGE Publishing
series Therapeutic Advances in Respiratory Disease
issn 1753-4666
publishDate 2020-05-01
description Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section.
url https://doi.org/10.1177/1753466620926800
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AT bingxiyan tnfainhibitormaybeeffectiveforseverecovid19learningfromtoxicepidermalnecrolysis
AT xiaoyongman tnfainhibitormaybeeffectiveforseverecovid19learningfromtoxicepidermalnecrolysis
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