Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified Electrode
In the present paper, the synthesis of cobalt ferrite/reduced graphene oxide (Co2Fe2O4/rGO) composite and its use for the simultaneous determination of uric acid (UA), xanthine (XA), and hypoxanthine (HX) is demonstrated. Cobalt ferrite hollow spheres were synthesized by using the carbonaceous polys...
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doaj-ecfb7eda32174409ab5dc0df487ec0e42020-11-25T03:02:50ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292020-01-01202010.1155/2020/97975099797509Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified ElectrodeNguyen Thi Vuong Hoan0Nguyen Ngoc Minh1Nguyen Thi Hong Trang2Le Thi Thanh Thuy3Cao Van Hoang4Tran Xuan Mau5Ho Xuan Anh Vu6Phan Thi Kim Thu7Nguyen Hai Phong8Dinh Quang Khieu9Quy Nhon University, 55000, VietnamQuy Nhon University, 55000, VietnamQuy Nhon University, 55000, VietnamQuy Nhon University, 55000, VietnamQuy Nhon University, 55000, VietnamHue University, 49000, VietnamUniversity of Sciences, Hue University, 49000, VietnamUniversity of Sciences, Hue University, 49000, VietnamUniversity of Sciences, Hue University, 49000, VietnamUniversity of Sciences, Hue University, 49000, VietnamIn the present paper, the synthesis of cobalt ferrite/reduced graphene oxide (Co2Fe2O4/rGO) composite and its use for the simultaneous determination of uric acid (UA), xanthine (XA), and hypoxanthine (HX) is demonstrated. Cobalt ferrite hollow spheres were synthesized by using the carbonaceous polysaccharide microspheres prepared from a D-glucose solution as templates, followed by calcination. The CoFe2O4/rGO composite was prepared with the ultrasound-assisted method. The obtained material was characterized by using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, EDX elemental mapping, and nitrogen adsorption/desorption isotherms. The electrochemical behavior of UA, XA, and HX on the CoFe2O4/rGO-modified electrode was studied with cyclic voltammetry and differential pulse voltammetry (DPV). The modified electrode exhibits excellent electrocatalytic activity towards the oxidation of the three compounds. The calibration curves for UA, XA, and HX were obtained over the range of 2.0–10.0 μM from DPV. The limits of detection for UA, XA, and HX are 0.767, 0.650, and 0.506 μM, respectively. The modified electrode was applied to the simultaneous detection of UA, XA, and HX in human urine, and the results are consistent with those obtained from the high-performance liquid chromatography technique.http://dx.doi.org/10.1155/2020/9797509 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nguyen Thi Vuong Hoan Nguyen Ngoc Minh Nguyen Thi Hong Trang Le Thi Thanh Thuy Cao Van Hoang Tran Xuan Mau Ho Xuan Anh Vu Phan Thi Kim Thu Nguyen Hai Phong Dinh Quang Khieu |
spellingShingle |
Nguyen Thi Vuong Hoan Nguyen Ngoc Minh Nguyen Thi Hong Trang Le Thi Thanh Thuy Cao Van Hoang Tran Xuan Mau Ho Xuan Anh Vu Phan Thi Kim Thu Nguyen Hai Phong Dinh Quang Khieu Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified Electrode Journal of Nanomaterials |
author_facet |
Nguyen Thi Vuong Hoan Nguyen Ngoc Minh Nguyen Thi Hong Trang Le Thi Thanh Thuy Cao Van Hoang Tran Xuan Mau Ho Xuan Anh Vu Phan Thi Kim Thu Nguyen Hai Phong Dinh Quang Khieu |
author_sort |
Nguyen Thi Vuong Hoan |
title |
Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified Electrode |
title_short |
Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified Electrode |
title_full |
Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified Electrode |
title_fullStr |
Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified Electrode |
title_full_unstemmed |
Simultaneous Voltammetric Determination of Uric Acid, Xanthine, and Hypoxanthine Using CoFe2O4/Reduced Graphene Oxide-Modified Electrode |
title_sort |
simultaneous voltammetric determination of uric acid, xanthine, and hypoxanthine using cofe2o4/reduced graphene oxide-modified electrode |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2020-01-01 |
description |
In the present paper, the synthesis of cobalt ferrite/reduced graphene oxide (Co2Fe2O4/rGO) composite and its use for the simultaneous determination of uric acid (UA), xanthine (XA), and hypoxanthine (HX) is demonstrated. Cobalt ferrite hollow spheres were synthesized by using the carbonaceous polysaccharide microspheres prepared from a D-glucose solution as templates, followed by calcination. The CoFe2O4/rGO composite was prepared with the ultrasound-assisted method. The obtained material was characterized by using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, EDX elemental mapping, and nitrogen adsorption/desorption isotherms. The electrochemical behavior of UA, XA, and HX on the CoFe2O4/rGO-modified electrode was studied with cyclic voltammetry and differential pulse voltammetry (DPV). The modified electrode exhibits excellent electrocatalytic activity towards the oxidation of the three compounds. The calibration curves for UA, XA, and HX were obtained over the range of 2.0–10.0 μM from DPV. The limits of detection for UA, XA, and HX are 0.767, 0.650, and 0.506 μM, respectively. The modified electrode was applied to the simultaneous detection of UA, XA, and HX in human urine, and the results are consistent with those obtained from the high-performance liquid chromatography technique. |
url |
http://dx.doi.org/10.1155/2020/9797509 |
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