Transcription elongation and tissue-specific somatic CAG instability.

Transcription elongation and tissue-specific somatic CAG instability.

The expansion of CAG/CTG repeats is responsible for many diseases, including Huntington's disease (HD) and myotonic dystrophy 1. CAG/CTG expansions are unstable in selective somatic tissues, which accelerates disease progression. The mechanisms underlying repeat instability are complex, and it...

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Bibliographic Details
Main Authors: Agathi-Vasiliki Goula, Agnieszka Stys, Jackson P K Chan, Yvon Trottier, Richard Festenstein, Karine Merienne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3510035?pdf=render

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