Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell identity in adult mice.

Bibliographic Details
Main Authors:	Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06307-w

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spelling	doaj-ecfdf3bfbfef42019680748d1efaa1ea2021-05-11T10:10:51ZengNature Publishing GroupNature Communications2041-17232018-10-019111510.1038/s41467-018-06307-wMechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervationLaura F. Corns0Stuart L. Johnson1Terri Roberts2Kishani M. Ranatunga3Aenea Hendry4Federico Ceriani5Saaid Safieddine6Karen P. Steel7Andy Forge8Christine Petit9David N. Furness10Corné J. Kros11Walter Marcotti12Department of Biomedical Science, University of SheffieldDepartment of Biomedical Science, University of SheffieldSchool of Life Sciences, University of Sussex, FalmerSchool of Life Sciences, University of Sussex, FalmerDepartment of Biomedical Science, University of SheffieldDepartment of Biomedical Science, University of SheffieldUnité de Génétique et Physiologie de l’Audition, Institut PasteurWolfson Centre for Age-Related Diseases, King’s College LondonUCL Ear Institute, University College LondonUnité de Génétique et Physiologie de l’Audition, Institut PasteurSchool of Life Sciences, Keele UniversitySchool of Life Sciences, University of Sussex, FalmerDepartment of Biomedical Science, University of SheffieldMechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell identity in adult mice.https://doi.org/10.1038/s41467-018-06307-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Laura F. Corns Stuart L. Johnson Terri Roberts Kishani M. Ranatunga Aenea Hendry Federico Ceriani Saaid Safieddine Karen P. Steel Andy Forge Christine Petit David N. Furness Corné J. Kros Walter Marcotti
spellingShingle	Laura F. Corns Stuart L. Johnson Terri Roberts Kishani M. Ranatunga Aenea Hendry Federico Ceriani Saaid Safieddine Karen P. Steel Andy Forge Christine Petit David N. Furness Corné J. Kros Walter Marcotti Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation Nature Communications
author_facet	Laura F. Corns Stuart L. Johnson Terri Roberts Kishani M. Ranatunga Aenea Hendry Federico Ceriani Saaid Safieddine Karen P. Steel Andy Forge Christine Petit David N. Furness Corné J. Kros Walter Marcotti
author_sort	Laura F. Corns
title	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
title_short	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
title_full	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
title_fullStr	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
title_full_unstemmed	Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
title_sort	mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell identity in adult mice.
url	https://doi.org/10.1038/s41467-018-06307-w
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Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation

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