Value of Zhuang medicine choerospondias axillaris bark for evaluating the expression of PTEN, VEGF in chronic wounds rats

• Main Authors: Xiao-Wei He, Xin Huang, Jia-Qi Di, Bing Wang, Xing Yin
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-06-01
• Series: Journal of Hainan Medical University
• Subjects: chronic wounds; choerospondias axillaris bark; cell ultrastructure; pten; vegf
• Online Access: http://www.hnykdxxb.com/PDF/201911/1.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine choerospondias axillaris bark. Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 groups: normal group, model group, MEBO group, choerospondias group. The normal group and model group were given external deposited normal saline external application. MEBO group used MEBT/MEBO. Choerospondias group was given external deposited choerospondias axillaris bark water decoction external application. Detected cell ultrastructure, PTEN、VEGF mRNA after 12 d. Results: The organelle structure in MEBO group and choerospondias group were restored. In 12 d, PTEN in MEBO group and choerospondias group were lower, VEGF were higher than 1 d (P<0.05). PTEN in MEBO group and choerospondias group were lower, VEGF were higher than model group (P<0.05). MEBO group had no difference with choerospondias group (P>0.05). Conclusion: Choerospondias axillaris bark water decoction could remarkably improve the cell ultrastructure in chronic wounds, regulate the PTEN signal conduction effect, and promote wound healing.