De novo mutational signature discovery in tumor genomes using SparseSignatures.
Cancer is the result of mutagenic processes that can be inferred from tumor genomes by analyzing rate spectra of point mutations, or "mutational signatures". Here we present SparseSignatures, a novel framework to extract signatures from somatic point mutation data. Our approach incorporate...
Main Authors: | Avantika Lal, Keli Liu, Robert Tibshirani, Arend Sidow, Daniele Ramazzotti |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-06-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1009119 |
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