The immune response to melanoma is limited by thymic selection of self-antigens.
The expression of melanoma-associated antigens (MAA) being limited to normal melanocytes and melanomas, MAAs are ideal targets for immunotherapy and melanoma vaccines. As MAAs are derived from self, immune responses to these may be limited by thymic tolerance. The extent to which self-tolerance prev...
Main Authors: | Ulrike Träger, Sophie Sierro, Gordana Djordjevic, Basma Bouzo, Shivani Khandwala, Antonella Meloni, Monika Mortensen, Anna Katharina Simon |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3323626?pdf=render |
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