tRNAs as Antibiotic Targets
Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple sta...
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| Format: | Article |
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MDPI AG
2014-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/16/1/321 |
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doaj-ed1a891e29fb4b44bb3bb8f857b9c8952020-11-24T23:40:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-12-0116132134910.3390/ijms16010321ijms16010321tRNAs as Antibiotic TargetsShaileja ChopraJohn ReaderTransfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial “stringent response” mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed.http://www.mdpi.com/1422-0067/16/1/321tRNAprotein translationantibioticsstringent responsebiogenesis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shaileja Chopra John Reader |
| spellingShingle |
Shaileja Chopra John Reader tRNAs as Antibiotic Targets International Journal of Molecular Sciences tRNA protein translation antibiotics stringent response biogenesis |
| author_facet |
Shaileja Chopra John Reader |
| author_sort |
Shaileja Chopra |
| title |
tRNAs as Antibiotic Targets |
| title_short |
tRNAs as Antibiotic Targets |
| title_full |
tRNAs as Antibiotic Targets |
| title_fullStr |
tRNAs as Antibiotic Targets |
| title_full_unstemmed |
tRNAs as Antibiotic Targets |
| title_sort |
trnas as antibiotic targets |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2014-12-01 |
| description |
Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial “stringent response” mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed. |
| topic |
tRNA protein translation antibiotics stringent response biogenesis |
| url |
http://www.mdpi.com/1422-0067/16/1/321 |
| work_keys_str_mv |
AT shailejachopra trnasasantibiotictargets AT johnreader trnasasantibiotictargets |
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1725508662930178048 |