Novel two-chain structure utilizing KIRS2/DAP12 domain improves the safety and efficacy of CAR-T cells in adults with r/r B-ALL
Engineered T cells that express chimeric antigen receptors (CARs) have been a promising therapy for hematologic malignancies. The optimization of CAR structure using different signaling domains can alter a wide range of CAR-T cell properties, including anti-tumor activity, long-term persistence, and...
Main Authors: | Ming Sun, Peipei Xu, Enxiu Wang, Min Zhou, Tongpeng Xu, Jing Wang, Qian Wang, Bo Wang, Kaihua Lu, Chen Wang, Bing Chen |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-12-01
|
Series: | Molecular Therapy: Oncolytics |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S237277052100125X |
Similar Items
-
TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway
by: Li Zhong, et al.
Published: (2017-06-01) -
DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D
by: Cui, Y., et al.
Published: (2022) -
Rhesus Macaque Activating Killer Immunoglobulin-Like Receptors Associate With Fc Receptor Gamma (FCER1G) and Not With DAP12 Adaptor Proteins Resulting in Stabilized Expression and Enabling Signal Transduction
by: Mohammad Zahidul Hasan, et al.
Published: (2021-04-01) -
Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS
by: Anna Kiialainen, et al.
Published: (2005-03-01) -
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19<sup>+</sup>HLA-C1<sup>−</sup> Malignant B Cells While Sparing CD19<sup>+</sup>HLA-C1<sup>+</sup> Healthy B Cells
by: Lei Tao, et al.
Published: (2020-09-01)