Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0]
The LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal development. The hippocampus is a structure t...
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doaj-ed22180fd6214abaa122ad0f0e8294962020-11-25T03:43:49ZengF1000 Research LtdF1000Research2046-14022013-10-01210.12688/f1000research.2-205.v11764Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0]Vanisha Lakhina0Lakshmi Subramanian1Dhananjay Huilgol2Ashwin S Shetty3Vidita A. Vaidya4Shubha Tole5Current affiliation: Lewis Sigler Institute for Integrative Genomics, Princeton University, NJ, USACurrent affiliation: Department of Neurology, University of California, San Francisco, CA, USACurrent affiliation: Cold Spring Harbor Laboratory, NY, USADepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, IndiaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, IndiaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, IndiaThe LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal development. The hippocampus is a structure that displays striking activity dependent plasticity. We examined whether LIM-HD genes and their co-factors are regulated during kainic acid induced seizure in the adult rat hippocampus as well as in early postnatal rats, when the hippocampal circuitry is not fully developed. We report a distinct and field-specific regulation of LIM-HD genes Lhx1, Lhx2, and Lhx9, LIM-only gene Lmo4, and cofactor Clim1a in the adult hippocampus after seizure induction. In contrast none of these genes displayed altered levels upon induction of seizure in postnatal animals. Our results provide evidence of temporal and spatial seizure mediated regulation of LIM-HD family members and suggest that LIM-HD gene function may be involved in activity dependent plasticity in the adult hippocampushttp://f1000research.com/articles/2-205/v1Control of Gene ExpressionNeurodevelopment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vanisha Lakhina Lakshmi Subramanian Dhananjay Huilgol Ashwin S Shetty Vidita A. Vaidya Shubha Tole |
spellingShingle |
Vanisha Lakhina Lakshmi Subramanian Dhananjay Huilgol Ashwin S Shetty Vidita A. Vaidya Shubha Tole Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0] F1000Research Control of Gene Expression Neurodevelopment |
author_facet |
Vanisha Lakhina Lakshmi Subramanian Dhananjay Huilgol Ashwin S Shetty Vidita A. Vaidya Shubha Tole |
author_sort |
Vanisha Lakhina |
title |
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0] |
title_short |
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0] |
title_full |
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0] |
title_fullStr |
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0] |
title_full_unstemmed |
Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0] |
title_sort |
seizure evoked regulation of lim-hd genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2013-10-01 |
description |
The LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal development. The hippocampus is a structure that displays striking activity dependent plasticity. We examined whether LIM-HD genes and their co-factors are regulated during kainic acid induced seizure in the adult rat hippocampus as well as in early postnatal rats, when the hippocampal circuitry is not fully developed. We report a distinct and field-specific regulation of LIM-HD genes Lhx1, Lhx2, and Lhx9, LIM-only gene Lmo4, and cofactor Clim1a in the adult hippocampus after seizure induction. In contrast none of these genes displayed altered levels upon induction of seizure in postnatal animals. Our results provide evidence of temporal and spatial seizure mediated regulation of LIM-HD family members and suggest that LIM-HD gene function may be involved in activity dependent plasticity in the adult hippocampus |
topic |
Control of Gene Expression Neurodevelopment |
url |
http://f1000research.com/articles/2-205/v1 |
work_keys_str_mv |
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