Host-Microbiome Interaction in Lung Cancer
Commensal microbiota has emerged as an essential biomarker and regulator of both tumorigenesis and response to cancer therapy. However, our current knowledge about microbiota in cancer has been largely limited to intestinal microbiota. As a mucosal organ harboring one of the largest surface areas in...
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doaj-ed2464d1b4db4ca8a655d3e14e1be1fb2021-05-24T14:34:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-05-011210.3389/fimmu.2021.679829679829Host-Microbiome Interaction in Lung CancerQiang Dong0Eric S. Chen1Chen Zhao2Chengcheng Jin3Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesThoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesCommensal microbiota has emerged as an essential biomarker and regulator of both tumorigenesis and response to cancer therapy. However, our current knowledge about microbiota in cancer has been largely limited to intestinal microbiota. As a mucosal organ harboring one of the largest surface areas in the body, the lung is exposed to a variety of microbes through inhalation and micro-aspiration, and is colonized by a diverse bacterial community in both physiological and pathological conditions. Importantly, increasing evidence has linked the lung microbiome to cancer development. Studies in lung cancer patients and mouse models have revealed tumor-associated dysregulation of the local microbiome in the lung, which in turn impacts cancer progression by shaping the tumor microenvironment and modulating the activity of tumor-infiltrating immune cells. These findings not only provide novel mechanistic insight into the biology of lung cancer but also shed light on new therapeutic targets and strategies for lung cancer prevention and treatment. The goal of this review is to discuss the key findings, remaining questions, and future directions in this new and exciting field.https://www.frontiersin.org/articles/10.3389/fimmu.2021.679829/fulllung cancermicrobiotacancer therapytumor microenvironment (TME)tumor immunologyGut-Lung Axis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiang Dong Eric S. Chen Chen Zhao Chengcheng Jin |
spellingShingle |
Qiang Dong Eric S. Chen Chen Zhao Chengcheng Jin Host-Microbiome Interaction in Lung Cancer Frontiers in Immunology lung cancer microbiota cancer therapy tumor microenvironment (TME) tumor immunology Gut-Lung Axis |
author_facet |
Qiang Dong Eric S. Chen Chen Zhao Chengcheng Jin |
author_sort |
Qiang Dong |
title |
Host-Microbiome Interaction in Lung Cancer |
title_short |
Host-Microbiome Interaction in Lung Cancer |
title_full |
Host-Microbiome Interaction in Lung Cancer |
title_fullStr |
Host-Microbiome Interaction in Lung Cancer |
title_full_unstemmed |
Host-Microbiome Interaction in Lung Cancer |
title_sort |
host-microbiome interaction in lung cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-05-01 |
description |
Commensal microbiota has emerged as an essential biomarker and regulator of both tumorigenesis and response to cancer therapy. However, our current knowledge about microbiota in cancer has been largely limited to intestinal microbiota. As a mucosal organ harboring one of the largest surface areas in the body, the lung is exposed to a variety of microbes through inhalation and micro-aspiration, and is colonized by a diverse bacterial community in both physiological and pathological conditions. Importantly, increasing evidence has linked the lung microbiome to cancer development. Studies in lung cancer patients and mouse models have revealed tumor-associated dysregulation of the local microbiome in the lung, which in turn impacts cancer progression by shaping the tumor microenvironment and modulating the activity of tumor-infiltrating immune cells. These findings not only provide novel mechanistic insight into the biology of lung cancer but also shed light on new therapeutic targets and strategies for lung cancer prevention and treatment. The goal of this review is to discuss the key findings, remaining questions, and future directions in this new and exciting field. |
topic |
lung cancer microbiota cancer therapy tumor microenvironment (TME) tumor immunology Gut-Lung Axis |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.679829/full |
work_keys_str_mv |
AT qiangdong hostmicrobiomeinteractioninlungcancer AT ericschen hostmicrobiomeinteractioninlungcancer AT chenzhao hostmicrobiomeinteractioninlungcancer AT chengchengjin hostmicrobiomeinteractioninlungcancer |
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