Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome
Prader-Willi syndrome (PWS) is a complex hypothalamic disorder. Features of PWS include hyperphagia, hypotonia, intellectual disability, and pituitary hormone deficiencies. The combination of growth hormone treatment and multidisciplinary care (GHMDc) has greatly improved the health of children with...
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doaj-ed2e83ff824546ee9bd8c6e262fb6fc32021-08-06T15:26:34ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-01103250325010.3390/jcm10153250Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi SyndromeKarlijn Pellikaan0Anna G. W. Rosenberg1Kirsten Davidse2Anja A. Kattentidt-Mouravieva3Rogier Kersseboom4Anja G. Bos-Roubos5Lionne N. Grootjen6Layla Damen7Sjoerd A. A. van den Berg8Aart J. van der Lely9Anita C. S. Hokken-Koelega10Laura C. G. de Graaff11Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Centre Rotterdam, 3015 GD Rotterdam, The NetherlandsDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Centre Rotterdam, 3015 GD Rotterdam, The NetherlandsDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Centre Rotterdam, 3015 GD Rotterdam, The NetherlandsStichting Zuidwester, 3241 LB Middelharnis, The NetherlandsStichting Zuidwester, 3241 LB Middelharnis, The NetherlandsCentre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, 5803 AC Venray, The NetherlandsDutch Center of Reference for Prader-Willi Syndrome, 3015 GD Rotterdam, The NetherlandsDutch Center of Reference for Prader-Willi Syndrome, 3015 GD Rotterdam, The NetherlandsDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Centre Rotterdam, 3015 GD Rotterdam, The NetherlandsDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Centre Rotterdam, 3015 GD Rotterdam, The NetherlandsDutch Center of Reference for Prader-Willi Syndrome, 3015 GD Rotterdam, The NetherlandsDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Centre Rotterdam, 3015 GD Rotterdam, The NetherlandsPrader-Willi syndrome (PWS) is a complex hypothalamic disorder. Features of PWS include hyperphagia, hypotonia, intellectual disability, and pituitary hormone deficiencies. The combination of growth hormone treatment and multidisciplinary care (GHMDc) has greatly improved the health of children with PWS. Little is known about the effects of childhood GHMDc on health outcomes in adulthood. We retrospectively collected clinical data of 109 adults with PWS. Thirty-nine had received GHMDc during childhood and adolescence (GHMDc+ group) and sixty-three had never received growth hormone treatment (GHt) nor multidisciplinary care (GHMDc− group). Our systematic screening revealed fewer undetected health problems in the GHMDc+ group (10%) than in the GHMDc− group (84%). All health problems revealed in the GHMDc+ group had developed between the last visit to the paediatric and the first visit to the adult clinic and/or did not require treatment. Mean BMI and the prevalence of diabetes mellitus type 2 were significantly lower in the GHMDc+ group compared to the GHMDc− group. As all patients who received GHt were treated in a multidisciplinary setting, it is unknown which effects are the result of GHt and which are the result of multidisciplinary care. However, our data clearly show that the combination of both has beneficial effects. Therefore, we recommend continuing GHMDc after patients with PWS have reached adult age.https://www.mdpi.com/2077-0383/10/15/3250Prader-Willi syndromecomorbiditytransition to adult caregrowth hormone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karlijn Pellikaan Anna G. W. Rosenberg Kirsten Davidse Anja A. Kattentidt-Mouravieva Rogier Kersseboom Anja G. Bos-Roubos Lionne N. Grootjen Layla Damen Sjoerd A. A. van den Berg Aart J. van der Lely Anita C. S. Hokken-Koelega Laura C. G. de Graaff |
spellingShingle |
Karlijn Pellikaan Anna G. W. Rosenberg Kirsten Davidse Anja A. Kattentidt-Mouravieva Rogier Kersseboom Anja G. Bos-Roubos Lionne N. Grootjen Layla Damen Sjoerd A. A. van den Berg Aart J. van der Lely Anita C. S. Hokken-Koelega Laura C. G. de Graaff Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome Journal of Clinical Medicine Prader-Willi syndrome comorbidity transition to adult care growth hormone |
author_facet |
Karlijn Pellikaan Anna G. W. Rosenberg Kirsten Davidse Anja A. Kattentidt-Mouravieva Rogier Kersseboom Anja G. Bos-Roubos Lionne N. Grootjen Layla Damen Sjoerd A. A. van den Berg Aart J. van der Lely Anita C. S. Hokken-Koelega Laura C. G. de Graaff |
author_sort |
Karlijn Pellikaan |
title |
Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome |
title_short |
Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome |
title_full |
Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome |
title_fullStr |
Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome |
title_full_unstemmed |
Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome |
title_sort |
effects of childhood multidisciplinary care and growth hormone treatment on health problems in adults with prader-willi syndrome |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-07-01 |
description |
Prader-Willi syndrome (PWS) is a complex hypothalamic disorder. Features of PWS include hyperphagia, hypotonia, intellectual disability, and pituitary hormone deficiencies. The combination of growth hormone treatment and multidisciplinary care (GHMDc) has greatly improved the health of children with PWS. Little is known about the effects of childhood GHMDc on health outcomes in adulthood. We retrospectively collected clinical data of 109 adults with PWS. Thirty-nine had received GHMDc during childhood and adolescence (GHMDc+ group) and sixty-three had never received growth hormone treatment (GHt) nor multidisciplinary care (GHMDc− group). Our systematic screening revealed fewer undetected health problems in the GHMDc+ group (10%) than in the GHMDc− group (84%). All health problems revealed in the GHMDc+ group had developed between the last visit to the paediatric and the first visit to the adult clinic and/or did not require treatment. Mean BMI and the prevalence of diabetes mellitus type 2 were significantly lower in the GHMDc+ group compared to the GHMDc− group. As all patients who received GHt were treated in a multidisciplinary setting, it is unknown which effects are the result of GHt and which are the result of multidisciplinary care. However, our data clearly show that the combination of both has beneficial effects. Therefore, we recommend continuing GHMDc after patients with PWS have reached adult age. |
topic |
Prader-Willi syndrome comorbidity transition to adult care growth hormone |
url |
https://www.mdpi.com/2077-0383/10/15/3250 |
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