Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation

Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation

We previously reported that deletion of Foxo1, via Ncr1-iCre mice from the expression of NKp46 onward, led to enhanced natural killer (NK) cell maturation and effector function. In this model, however, the role of Foxo1 in regulating NK cell specification and early development remains exclusive. Her...

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Bibliographic Details
Main Authors: Pei Huang, Fangjie Wang, Yao Yang, Wenjing Lai, Meng Meng, Shuting Wu, Hongyan Peng, Lili Wang, Rixing Zhan, Saber Imani, Jianhua Yu, Bingbo Chen, Xiaohui Li, Youcai Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
Foxo1
natural killer cell
NK specification
NK proliferation
cell cycle
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01016/full

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