Research Progress of Sirtuin4 in Cancer
Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located ma...
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doaj-ed376b8ece2b4bc7b437514b1f02c85d2021-01-08T06:47:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.562950562950Research Progress of Sirtuin4 in CancerYibing Bai0Yibing Bai1Jiani Yang2Jiani Yang3Ying Cui4Ying Cui5Yuanfei Yao6Yuanfei Yao7Feng Wu8Caiqi Liu9Xiaona Fan10Yanqiao Zhang11Yanqiao Zhang12Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaSirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms.https://www.frontiersin.org/articles/10.3389/fonc.2020.562950/fullsirtuin4cancerstructurelocalizationenzymatic activitiesmetabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yibing Bai Yibing Bai Jiani Yang Jiani Yang Ying Cui Ying Cui Yuanfei Yao Yuanfei Yao Feng Wu Caiqi Liu Xiaona Fan Yanqiao Zhang Yanqiao Zhang |
spellingShingle |
Yibing Bai Yibing Bai Jiani Yang Jiani Yang Ying Cui Ying Cui Yuanfei Yao Yuanfei Yao Feng Wu Caiqi Liu Xiaona Fan Yanqiao Zhang Yanqiao Zhang Research Progress of Sirtuin4 in Cancer Frontiers in Oncology sirtuin4 cancer structure localization enzymatic activities metabolism |
author_facet |
Yibing Bai Yibing Bai Jiani Yang Jiani Yang Ying Cui Ying Cui Yuanfei Yao Yuanfei Yao Feng Wu Caiqi Liu Xiaona Fan Yanqiao Zhang Yanqiao Zhang |
author_sort |
Yibing Bai |
title |
Research Progress of Sirtuin4 in Cancer |
title_short |
Research Progress of Sirtuin4 in Cancer |
title_full |
Research Progress of Sirtuin4 in Cancer |
title_fullStr |
Research Progress of Sirtuin4 in Cancer |
title_full_unstemmed |
Research Progress of Sirtuin4 in Cancer |
title_sort |
research progress of sirtuin4 in cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-01-01 |
description |
Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms. |
topic |
sirtuin4 cancer structure localization enzymatic activities metabolism |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.562950/full |
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