Research Progress of Sirtuin4 in Cancer

Research Progress of Sirtuin4 in Cancer

Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located ma...

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Main Authors: Yibing Bai, Jiani Yang, Ying Cui, Yuanfei Yao, Feng Wu, Caiqi Liu, Xiaona Fan, Yanqiao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
sirtuin4
cancer
structure
localization
enzymatic activities
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.562950/full
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spelling doaj-ed376b8ece2b4bc7b437514b1f02c85d2021-01-08T06:47:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.562950562950Research Progress of Sirtuin4 in CancerYibing Bai0Yibing Bai1Jiani Yang2Jiani Yang3Ying Cui4Ying Cui5Yuanfei Yao6Yuanfei Yao7Feng Wu8Caiqi Liu9Xiaona Fan10Yanqiao Zhang11Yanqiao Zhang12Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaTranslational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, ChinaSirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms.https://www.frontiersin.org/articles/10.3389/fonc.2020.562950/fullsirtuin4cancerstructurelocalizationenzymatic activitiesmetabolism
collection DOAJ
language English
format Article
sources DOAJ
author Yibing Bai
Yibing Bai
Jiani Yang
Jiani Yang
Ying Cui
Ying Cui
Yuanfei Yao
Yuanfei Yao
Feng Wu
Caiqi Liu
Xiaona Fan
Yanqiao Zhang
Yanqiao Zhang
spellingShingle Yibing Bai
Yibing Bai
Jiani Yang
Jiani Yang
Ying Cui
Ying Cui
Yuanfei Yao
Yuanfei Yao
Feng Wu
Caiqi Liu
Xiaona Fan
Yanqiao Zhang
Yanqiao Zhang
Research Progress of Sirtuin4 in Cancer
Frontiers in Oncology
sirtuin4
cancer
structure
localization
enzymatic activities
metabolism
author_facet Yibing Bai
Yibing Bai
Jiani Yang
Jiani Yang
Ying Cui
Ying Cui
Yuanfei Yao
Yuanfei Yao
Feng Wu
Caiqi Liu
Xiaona Fan
Yanqiao Zhang
Yanqiao Zhang
author_sort Yibing Bai
title Research Progress of Sirtuin4 in Cancer
title_short Research Progress of Sirtuin4 in Cancer
title_full Research Progress of Sirtuin4 in Cancer
title_fullStr Research Progress of Sirtuin4 in Cancer
title_full_unstemmed Research Progress of Sirtuin4 in Cancer
title_sort research progress of sirtuin4 in cancer
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2021-01-01
description Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms.
topic sirtuin4
cancer
structure
localization
enzymatic activities
metabolism
url https://www.frontiersin.org/articles/10.3389/fonc.2020.562950/full
work_keys_str_mv AT yibingbai researchprogressofsirtuin4incancer
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