Evaluation of the prognostic value of CBXs in gastric cancer patients
Abstract Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) r...
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doaj-ed45b062617746aa8ae15c9c8f7a72bb2021-06-13T11:38:02ZengNature Publishing GroupScientific Reports2045-23222021-06-011111910.1038/s41598-021-91649-7Evaluation of the prognostic value of CBXs in gastric cancer patientsMengya He0Limin Yue1Haiyan Wang2Feiyan Yu3Mingyang Yu4Peng Ni5Ke Zhang6Shuaiyin Chen7Guangcai Duan8Rongguang Zhang9Department of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology, College of Public Health, Hainan Medical University, Longhua DistrictAbstract Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) remain unclear. The current study investigated the roles of CBXs in the prognosis of GC using the Oncomine, The Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, The Cancer Genome Atlas (TCGA), and cBioPortal databases. CBX1/2/3/4/5 were significantly upregulated in GC tissues compared with normal tissues, and CBX7 was downregulated. Multivariate analysis showed that high mRNA expression levels of CBX3/8 were independent prognostic factors for prolonged OS in GC patients. In addition, the genetic mutation rate of CBXs was 37% in GC patients, and genetic alterations in CBXs showed no association with OS or disease-free survival (DFS) in GC patients. These results indicated that CBX3/8 can be prognostic biomarkers for the survival of GC patients.https://doi.org/10.1038/s41598-021-91649-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mengya He Limin Yue Haiyan Wang Feiyan Yu Mingyang Yu Peng Ni Ke Zhang Shuaiyin Chen Guangcai Duan Rongguang Zhang |
spellingShingle |
Mengya He Limin Yue Haiyan Wang Feiyan Yu Mingyang Yu Peng Ni Ke Zhang Shuaiyin Chen Guangcai Duan Rongguang Zhang Evaluation of the prognostic value of CBXs in gastric cancer patients Scientific Reports |
author_facet |
Mengya He Limin Yue Haiyan Wang Feiyan Yu Mingyang Yu Peng Ni Ke Zhang Shuaiyin Chen Guangcai Duan Rongguang Zhang |
author_sort |
Mengya He |
title |
Evaluation of the prognostic value of CBXs in gastric cancer patients |
title_short |
Evaluation of the prognostic value of CBXs in gastric cancer patients |
title_full |
Evaluation of the prognostic value of CBXs in gastric cancer patients |
title_fullStr |
Evaluation of the prognostic value of CBXs in gastric cancer patients |
title_full_unstemmed |
Evaluation of the prognostic value of CBXs in gastric cancer patients |
title_sort |
evaluation of the prognostic value of cbxs in gastric cancer patients |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-06-01 |
description |
Abstract Chromobox (CBX) proteins were suggested to exert epigenetic regulatory and transcriptionally repressing effects on target genes and might play key roles in the carcinogenesis of a variety of carcinomas. Nevertheless, the functions and prognostic significance of CBXs in gastric cancer (GC) remain unclear. The current study investigated the roles of CBXs in the prognosis of GC using the Oncomine, The Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, The Cancer Genome Atlas (TCGA), and cBioPortal databases. CBX1/2/3/4/5 were significantly upregulated in GC tissues compared with normal tissues, and CBX7 was downregulated. Multivariate analysis showed that high mRNA expression levels of CBX3/8 were independent prognostic factors for prolonged OS in GC patients. In addition, the genetic mutation rate of CBXs was 37% in GC patients, and genetic alterations in CBXs showed no association with OS or disease-free survival (DFS) in GC patients. These results indicated that CBX3/8 can be prognostic biomarkers for the survival of GC patients. |
url |
https://doi.org/10.1038/s41598-021-91649-7 |
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