HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response

HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response

The mitochondrial unfolded protein response (UPRmt) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cells. However, the detailed mechanisms underlying the...

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Bibliographic Details
Main Authors: Arpit Katiyar, Mitsuaki Fujimoto, Ke Tan, Ai Kurashima, Pratibha Srivastava, Mariko Okada, Ryosuke Takii, Akira Nakai
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:FEBS Open Bio
Subjects:
heat shock protein
HSF1
mitochondria
proteostasis
proteotoxic stress
SSBP1
Online Access:https://doi.org/10.1002/2211-5463.12863

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