Darier’s Disease Flare following COVID-19 Vaccine
Darier’s disease is a rare genodermatosis characterized clinically by dyskeratotic papules in the seborrheic and intertriginous areas and nail abnormalities. Dyskeratosis and acantholysis are typical histological findings. Darier’s disease is not known to be inflammatory by nature as inflammation oc...
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doaj-ed56b52269904288bd1af3f2af34e4ea2021-09-16T08:40:56ZengKarger PublishersCase Reports in Dermatology1662-65672021-08-0113243243610.1159/000517256517256Darier’s Disease Flare following COVID-19 VaccineMette Vestergaard Elbæk0https://orcid.org/0000-0003-2378-2511Gabrielle Randskov Vinding1Gregor Borut Ernst Jemec2https://orcid.org/0000-0002-0712-2540Department of Dermatology, Zealand University Hospital, Roskilde, DenmarkDepartment of Dermatology, Zealand University Hospital, Roskilde, DenmarkDepartment of Dermatology, Zealand University Hospital, Roskilde, DenmarkDarier’s disease is a rare genodermatosis characterized clinically by dyskeratotic papules in the seborrheic and intertriginous areas and nail abnormalities. Dyskeratosis and acantholysis are typical histological findings. Darier’s disease is not known to be inflammatory by nature as inflammation occurs primarily due to local infections, and it may therefore differ from inflammatory dermatoses such as psoriasis and cutaneous lupus in response to antigen stimulation. Known triggers of Darier’s disease primarily include exogenous factors such as sun exposure, friction, or infection. We present a case of a 47-year-old white female with a flare of Darier’s disease 2 days following her first vaccination with COVID-19 vaccine (ChAdOx1-s [recombinant]) (Vaxzevria® [previously known as COVID-19 vaccine AstraZeneca]). In this case report, we discuss possible mechanisms linking the vaccination and the flare of Darier’s disease. We consider inflammatory mechanisms as well as a random co-occurrence. Due to the close time-related association between the disease flare and the COVID-19 vaccination, we find an urge to make other clinicians aware of a possible association.https://www.karger.com/Article/FullText/517256darier’s diseasedisease flaregenodermatosiscovid-19 vaccinevaccination |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mette Vestergaard Elbæk Gabrielle Randskov Vinding Gregor Borut Ernst Jemec |
spellingShingle |
Mette Vestergaard Elbæk Gabrielle Randskov Vinding Gregor Borut Ernst Jemec Darier’s Disease Flare following COVID-19 Vaccine Case Reports in Dermatology darier’s disease disease flare genodermatosis covid-19 vaccine vaccination |
author_facet |
Mette Vestergaard Elbæk Gabrielle Randskov Vinding Gregor Borut Ernst Jemec |
author_sort |
Mette Vestergaard Elbæk |
title |
Darier’s Disease Flare following COVID-19 Vaccine |
title_short |
Darier’s Disease Flare following COVID-19 Vaccine |
title_full |
Darier’s Disease Flare following COVID-19 Vaccine |
title_fullStr |
Darier’s Disease Flare following COVID-19 Vaccine |
title_full_unstemmed |
Darier’s Disease Flare following COVID-19 Vaccine |
title_sort |
darier’s disease flare following covid-19 vaccine |
publisher |
Karger Publishers |
series |
Case Reports in Dermatology |
issn |
1662-6567 |
publishDate |
2021-08-01 |
description |
Darier’s disease is a rare genodermatosis characterized clinically by dyskeratotic papules in the seborrheic and intertriginous areas and nail abnormalities. Dyskeratosis and acantholysis are typical histological findings. Darier’s disease is not known to be inflammatory by nature as inflammation occurs primarily due to local infections, and it may therefore differ from inflammatory dermatoses such as psoriasis and cutaneous lupus in response to antigen stimulation. Known triggers of Darier’s disease primarily include exogenous factors such as sun exposure, friction, or infection. We present a case of a 47-year-old white female with a flare of Darier’s disease 2 days following her first vaccination with COVID-19 vaccine (ChAdOx1-s [recombinant]) (Vaxzevria® [previously known as COVID-19 vaccine AstraZeneca]). In this case report, we discuss possible mechanisms linking the vaccination and the flare of Darier’s disease. We consider inflammatory mechanisms as well as a random co-occurrence. Due to the close time-related association between the disease flare and the COVID-19 vaccination, we find an urge to make other clinicians aware of a possible association. |
topic |
darier’s disease disease flare genodermatosis covid-19 vaccine vaccination |
url |
https://www.karger.com/Article/FullText/517256 |
work_keys_str_mv |
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