Comparison of the Efficacy and Safety of Icotinib with Standard Second-line Chemotherapy in Previously Treated Advanced Non-small Cell Lung Cancer
Background and objective This study compared the efficacy and safety of icotinib with standard second-line chemotherapy (single-agent docetaxel or pemetrexed) in previously treated advanced non-small cell lung cancer (NSCLC). Methods Thirty-two consecutive patients treated with icotinib and 33 conse...
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2015-06-01
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Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2015.06.07 |
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doaj-ed576876d44f4c47a0e31c1e290544262020-11-24T22:50:33ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872015-06-0118636937310.3779/j.issn.1009-3419.2015.06.07Comparison of the Efficacy and Safety of Icotinib with Standard Second-line
Chemotherapy in Previously Treated Advanced Non-small Cell Lung CancerShuyang YAO0Kun QIAN1Ruotian WANG2Yuanbo LI3Yi ZHANG4Department of Thoracic Surgery, Xuanwu Hospital Capital Medical University, Beijing 100053, ChinaDepartment of Thoracic Surgery, Xuanwu Hospital Capital Medical University, Beijing 100053, ChinaDepartment of Thoracic Surgery, Xuanwu Hospital Capital Medical University, Beijing 100053, ChinaDepartment of Thoracic Surgery, Xuanwu Hospital Capital Medical University, Beijing 100053, ChinaDepartment of Thoracic Surgery, Xuanwu Hospital Capital Medical University, Beijing 100053, ChinaBackground and objective This study compared the efficacy and safety of icotinib with standard second-line chemotherapy (single-agent docetaxel or pemetrexed) in previously treated advanced non-small cell lung cancer (NSCLC). Methods Thirty-two consecutive patients treated with icotinib and 33 consecutive patients treated with standard second-line chemotherapy in Xuanwu Hospital from January 2012 to July 2013 were enrolled in our retrospective research. The Response Evaluation Criteria in Solid Tumors were used to evaluate the tumor responses, and the progression-free survival (PFS) was evaluated by Kaplan-Meier method. Results Icotinib was comparable with standard second-line chemotherapy for advanced NSCLC in terms of overall response rate (ORR) (28.1% vs 18.2%, P=0.341), disease control rate (DFS)(43.8% vs 45.5%, P=0.890), and PFS (4.3 months vs 3.8 months, P=0.506). In the icotinib group, the ORR of epidermal growth factor receptor (EGFR) mutant was significantly higher than that of EGFR unknown or wild type (P=0.017). In multivariate analysis, age, gender, histology, and the optimum first-line treatment response were dependent prognostic factors based on the PFS of the icotinib group. The incidence of adverse events was significantly fewer in the icotinib group than in the chemotherapy group (P=0.001). Conclusion Compared with the standard second-line chemotherapy, icotinib is active in the treatment of advanced NSCLC patients, especially with EGFR unknown in the second line, with an acceptable adverse event profile.http://dx.doi.org/10.3779/j.issn.1009-3419.2015.06.07Lung neoplasmsIcotinibChemotherapy |
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DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
Shuyang YAO Kun QIAN Ruotian WANG Yuanbo LI Yi ZHANG |
spellingShingle |
Shuyang YAO Kun QIAN Ruotian WANG Yuanbo LI Yi ZHANG Comparison of the Efficacy and Safety of Icotinib with Standard Second-line Chemotherapy in Previously Treated Advanced Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms Icotinib Chemotherapy |
author_facet |
Shuyang YAO Kun QIAN Ruotian WANG Yuanbo LI Yi ZHANG |
author_sort |
Shuyang YAO |
title |
Comparison of the Efficacy and Safety of Icotinib with Standard Second-line
Chemotherapy in Previously Treated Advanced Non-small Cell Lung Cancer |
title_short |
Comparison of the Efficacy and Safety of Icotinib with Standard Second-line
Chemotherapy in Previously Treated Advanced Non-small Cell Lung Cancer |
title_full |
Comparison of the Efficacy and Safety of Icotinib with Standard Second-line
Chemotherapy in Previously Treated Advanced Non-small Cell Lung Cancer |
title_fullStr |
Comparison of the Efficacy and Safety of Icotinib with Standard Second-line
Chemotherapy in Previously Treated Advanced Non-small Cell Lung Cancer |
title_full_unstemmed |
Comparison of the Efficacy and Safety of Icotinib with Standard Second-line
Chemotherapy in Previously Treated Advanced Non-small Cell Lung Cancer |
title_sort |
comparison of the efficacy and safety of icotinib with standard second-line
chemotherapy in previously treated advanced non-small cell lung cancer |
publisher |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
series |
Chinese Journal of Lung Cancer |
issn |
1009-3419 1999-6187 |
publishDate |
2015-06-01 |
description |
Background and objective This study compared the efficacy and safety of icotinib with standard second-line chemotherapy (single-agent docetaxel or pemetrexed) in previously treated advanced non-small cell lung cancer (NSCLC). Methods Thirty-two consecutive patients treated with icotinib and 33 consecutive patients treated with standard second-line chemotherapy in Xuanwu Hospital from January 2012 to July 2013 were enrolled in our retrospective research. The Response Evaluation Criteria in Solid Tumors were used to evaluate the tumor responses, and the progression-free survival (PFS) was evaluated by Kaplan-Meier method. Results Icotinib was comparable with standard second-line chemotherapy for advanced NSCLC in terms of overall response rate (ORR) (28.1% vs 18.2%, P=0.341), disease control rate (DFS)(43.8% vs 45.5%, P=0.890), and PFS (4.3 months vs 3.8 months, P=0.506). In the icotinib group, the ORR of epidermal growth factor receptor (EGFR) mutant was significantly higher than that of EGFR unknown or wild type (P=0.017). In multivariate analysis, age, gender, histology, and the optimum first-line treatment response were dependent prognostic factors based on the PFS of the icotinib group. The incidence of adverse events was significantly fewer in the icotinib group than in the chemotherapy group (P=0.001). Conclusion Compared with the standard second-line chemotherapy, icotinib is active in the treatment of advanced NSCLC patients, especially with EGFR unknown in the second line, with an acceptable adverse event profile. |
topic |
Lung neoplasms Icotinib Chemotherapy |
url |
http://dx.doi.org/10.3779/j.issn.1009-3419.2015.06.07 |
work_keys_str_mv |
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1725672118705717248 |