<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia

The incidence of dementia is on the rise and expected to continue to increase in the foreseeable future. Two of the most common subtypes of dementia are Alzheimer’s subtype and vascular dementia. Hyperhomocysteinemia has been shown to serve as a risk factor for dementia due to an associate...

Full description

Bibliographic Details
Main Authors:	Christian E. Cajavilca, Rajan R. Gadhia, Gustavo C. Román
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Brain Sciences
Subjects:	<i>MTHFR</i> gene dementia homocysteine Alzheimer’s disease
Online Access:	https://www.mdpi.com/2076-3425/9/9/211

id	doaj-ed6620ce4e3d4e09876c4be64e211054
record_format	Article
spelling	doaj-ed6620ce4e3d4e09876c4be64e2110542020-11-25T00:55:18ZengMDPI AGBrain Sciences2076-34252019-08-019921110.3390/brainsci9090211brainsci9090211<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and DementiaChristian E. Cajavilca0Rajan R. Gadhia1Gustavo C. Román2Vascular Neurology, Houston Methodist Hospital Neurological Institute, Houston, TX 77030, USAVascular Neurology, Houston Methodist Hospital Neurological Institute, Houston, TX 77030, USAAlzheimer Clinic, Houston Methodist Hospital Neurological Institute, Houston, TX 77030, USAThe incidence of dementia is on the rise and expected to continue to increase in the foreseeable future. Two of the most common subtypes of dementia are Alzheimer’s subtype and vascular dementia. Hyperhomocysteinemia has been shown to serve as a risk factor for dementia due to an associated blood−brain barrier dysfunction and subsequent small-vessel disease pathology. There are varying causes for hyperhomocysteinemia, including genetic and dietary, among others. We highlight the importance of identifying hyperhomocysteinemia as a potential etiologic and therapeutic target for the most common subtypes of dementia.https://www.mdpi.com/2076-3425/9/9/211<i>MTHFR</i> genedementiahomocysteineAlzheimer’s disease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christian E. Cajavilca Rajan R. Gadhia Gustavo C. Román
spellingShingle	Christian E. Cajavilca Rajan R. Gadhia Gustavo C. Román <i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia Brain Sciences <i>MTHFR</i> gene dementia homocysteine Alzheimer’s disease
author_facet	Christian E. Cajavilca Rajan R. Gadhia Gustavo C. Román
author_sort	Christian E. Cajavilca
title	<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia
title_short	<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia
title_full	<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia
title_fullStr	<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia
title_full_unstemmed	<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia
title_sort	<i>mthfr</i> gene mutations correlate with white matter disease burden and predict cerebrovascular disease and dementia
publisher	MDPI AG
series	Brain Sciences
issn	2076-3425
publishDate	2019-08-01
description	The incidence of dementia is on the rise and expected to continue to increase in the foreseeable future. Two of the most common subtypes of dementia are Alzheimer’s subtype and vascular dementia. Hyperhomocysteinemia has been shown to serve as a risk factor for dementia due to an associated blood−brain barrier dysfunction and subsequent small-vessel disease pathology. There are varying causes for hyperhomocysteinemia, including genetic and dietary, among others. We highlight the importance of identifying hyperhomocysteinemia as a potential etiologic and therapeutic target for the most common subtypes of dementia.
topic	<i>MTHFR</i> gene dementia homocysteine Alzheimer’s disease
url	https://www.mdpi.com/2076-3425/9/9/211
work_keys_str_mv	AT christianecajavilca imthfrigenemutationscorrelatewithwhitematterdiseaseburdenandpredictcerebrovasculardiseaseanddementia AT rajanrgadhia imthfrigenemutationscorrelatewithwhitematterdiseaseburdenandpredictcerebrovasculardiseaseanddementia AT gustavocroman imthfrigenemutationscorrelatewithwhitematterdiseaseburdenandpredictcerebrovasculardiseaseanddementia
_version_	1725230862335737856

<i>MTHFR</i> Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia

Similar Items