Contribution of hypoxia inducible factor-1 during viral infections
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the n...
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2020-01-01
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Online Access: | http://dx.doi.org/10.1080/21505594.2020.1836904 |
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doaj-ed70e18c4a6a4787be7aeb11fc0b7f412021-01-15T14:09:08ZengTaylor & Francis GroupVirulence2150-55942150-56082020-01-011111482150010.1080/21505594.2020.18369041836904Contribution of hypoxia inducible factor-1 during viral infectionsAntonia Reyes0Nicolás Corrales1Nicolás M. S. Gálvez2Susan M. Bueno3Alexis M. Kalergis4Pablo A. González5Facultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileHypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections.http://dx.doi.org/10.1080/21505594.2020.1836904hypoxianormoxiarna virusesdna virusesvirus life cycleviral treatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonia Reyes Nicolás Corrales Nicolás M. S. Gálvez Susan M. Bueno Alexis M. Kalergis Pablo A. González |
spellingShingle |
Antonia Reyes Nicolás Corrales Nicolás M. S. Gálvez Susan M. Bueno Alexis M. Kalergis Pablo A. González Contribution of hypoxia inducible factor-1 during viral infections Virulence hypoxia normoxia rna viruses dna viruses virus life cycle viral treatment |
author_facet |
Antonia Reyes Nicolás Corrales Nicolás M. S. Gálvez Susan M. Bueno Alexis M. Kalergis Pablo A. González |
author_sort |
Antonia Reyes |
title |
Contribution of hypoxia inducible factor-1 during viral infections |
title_short |
Contribution of hypoxia inducible factor-1 during viral infections |
title_full |
Contribution of hypoxia inducible factor-1 during viral infections |
title_fullStr |
Contribution of hypoxia inducible factor-1 during viral infections |
title_full_unstemmed |
Contribution of hypoxia inducible factor-1 during viral infections |
title_sort |
contribution of hypoxia inducible factor-1 during viral infections |
publisher |
Taylor & Francis Group |
series |
Virulence |
issn |
2150-5594 2150-5608 |
publishDate |
2020-01-01 |
description |
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections. |
topic |
hypoxia normoxia rna viruses dna viruses virus life cycle viral treatment |
url |
http://dx.doi.org/10.1080/21505594.2020.1836904 |
work_keys_str_mv |
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