Applying Non-canonical Redox Cofactors in Fermentation Processes

Summary: Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons i...

Full description

Bibliographic Details
Main Authors: Ruud A. Weusthuis, Pauline L. Folch, Ana Pozo-Rodríguez, Caroline E. Paul
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306635
Description
Summary:Summary: Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons is therefore crucial. However, electron transfer via redox cofactors results in a diffuse distribution of electrons over metabolism. To overcome this challenge, we propose to apply non-canonical redox cofactors (NRCs) in metabolic networks: cofactors that channel electrons exclusively from substrate to product, forming orthogonal circuits for electron transfer.
ISSN:2589-0042