Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults
Abstract Background Metabolic imbalance is a key determinant of risk of chronic diseases. Metabolic health cannot be assessed solely by body mass calculations or by static, fasted state biochemical readouts. Although previous studies have described temporal responses to dietary challenges, these stu...
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doaj-ed768663b96f47f1bca33caf8b013d5c2020-11-24T22:52:53ZengBMCBMC Nutrition2055-09282017-10-013111310.1186/s40795-017-0197-4Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adultsLacey M. Baldiviez0Nancy L. Keim1Kevin D. Laugero2Daniel H. Hwang3Liping Huang4Leslie R. Woodhouse5Dustin J. Burnett6Melissa S. Zerofsky7Ellen L. Bonnel8Lindsay H. Allen9John W. Newman10Charles B. Stephensen11United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research CenterAbstract Background Metabolic imbalance is a key determinant of risk of chronic diseases. Metabolic health cannot be assessed solely by body mass calculations or by static, fasted state biochemical readouts. Although previous studies have described temporal responses to dietary challenges, these studies fail to assess the environmental factors associated with certain metabolic phenotypes and therefore, provide little scientific rationale for potentially effective intervention strategies. Methods/design In this phenotyping study of healthy US adults, we are evaluating lifestyle, biological and environmental factors in addition to metabolic parameters to determine the factors associated with variations in metabolic health. A series of practical fitness, dietary, and emotional challenges are introduced and temporal responses in various areas of specialization, including immunology, metabolomics, and endocrinology, are monitored. We expect that this study will identify key factors related to healthy or unhealthy metabolic phenotypes (metabotypes) that may be modifiable targets for the prevention of chronic diseases in an individual. Discussion This study will provide novel insights into metabolic variability among healthy adults in balanced strata defined by sex, age and body mass index. Usual dietary intake and physical activity will be evaluated across these strata to determine how diet is associated with health status defined using many indicators including immune function, metabolism, body composition, physiology, response to exercise andmeal challenges and neuroendocrine assessment. A principal study goal is to identify dietary and other personal factors that will differentiate different levels of "health" among study participants. Trial registration ClinicalTrials.gov NCT02367287 .http://link.springer.com/article/10.1186/s40795-017-0197-4DietMetabolismPhenotypeMetabotypesGut microbiotaMetabolomics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lacey M. Baldiviez Nancy L. Keim Kevin D. Laugero Daniel H. Hwang Liping Huang Leslie R. Woodhouse Dustin J. Burnett Melissa S. Zerofsky Ellen L. Bonnel Lindsay H. Allen John W. Newman Charles B. Stephensen |
spellingShingle |
Lacey M. Baldiviez Nancy L. Keim Kevin D. Laugero Daniel H. Hwang Liping Huang Leslie R. Woodhouse Dustin J. Burnett Melissa S. Zerofsky Ellen L. Bonnel Lindsay H. Allen John W. Newman Charles B. Stephensen Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults BMC Nutrition Diet Metabolism Phenotype Metabotypes Gut microbiota Metabolomics |
author_facet |
Lacey M. Baldiviez Nancy L. Keim Kevin D. Laugero Daniel H. Hwang Liping Huang Leslie R. Woodhouse Dustin J. Burnett Melissa S. Zerofsky Ellen L. Bonnel Lindsay H. Allen John W. Newman Charles B. Stephensen |
author_sort |
Lacey M. Baldiviez |
title |
Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults |
title_short |
Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults |
title_full |
Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults |
title_fullStr |
Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults |
title_full_unstemmed |
Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults |
title_sort |
design and implementation of a cross-sectional nutritional phenotyping study in healthy us adults |
publisher |
BMC |
series |
BMC Nutrition |
issn |
2055-0928 |
publishDate |
2017-10-01 |
description |
Abstract Background Metabolic imbalance is a key determinant of risk of chronic diseases. Metabolic health cannot be assessed solely by body mass calculations or by static, fasted state biochemical readouts. Although previous studies have described temporal responses to dietary challenges, these studies fail to assess the environmental factors associated with certain metabolic phenotypes and therefore, provide little scientific rationale for potentially effective intervention strategies. Methods/design In this phenotyping study of healthy US adults, we are evaluating lifestyle, biological and environmental factors in addition to metabolic parameters to determine the factors associated with variations in metabolic health. A series of practical fitness, dietary, and emotional challenges are introduced and temporal responses in various areas of specialization, including immunology, metabolomics, and endocrinology, are monitored. We expect that this study will identify key factors related to healthy or unhealthy metabolic phenotypes (metabotypes) that may be modifiable targets for the prevention of chronic diseases in an individual. Discussion This study will provide novel insights into metabolic variability among healthy adults in balanced strata defined by sex, age and body mass index. Usual dietary intake and physical activity will be evaluated across these strata to determine how diet is associated with health status defined using many indicators including immune function, metabolism, body composition, physiology, response to exercise andmeal challenges and neuroendocrine assessment. A principal study goal is to identify dietary and other personal factors that will differentiate different levels of "health" among study participants. Trial registration ClinicalTrials.gov NCT02367287 . |
topic |
Diet Metabolism Phenotype Metabotypes Gut microbiota Metabolomics |
url |
http://link.springer.com/article/10.1186/s40795-017-0197-4 |
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