Aromatase Inhibitors Plus Weight Loss Improves the Hormonal Profile of Obese Hypogonadal Men Without Causing Major Side Effects

Aromatase Inhibitors Plus Weight Loss Improves the Hormonal Profile of Obese Hypogonadal Men Without Causing Major Side Effects

Objective: In obese men, the increased expression of the aromatase enzyme in adipose tissue leads to high conversion of androgens to estrogens contributing to hypogonadotropic hypogonadism (HHG). Our objective is to evaluate efficacy and safety of weight loss (WL) plus aromatase inhibitor (AI) thera...

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Bibliographic Details
Main Authors: Georgia Colleluori, Rui Chen, Christie G. Turin, Francesca Vigevano, Clifford Qualls, Biju Johnson, Sanjay Mediwala, Dennis T. Villareal, Reina Armamento-Villareal
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Endocrinology
Subjects:
hypogonadism
obesity
aromatase inhibitors
weight loss
sex hormones
bone density
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00277/full

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