Olmesartan inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch through the inhibition of the c-Jun N-terminal kinase and p38 signaling pathways

Olmesartan inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch through the inhibition of the c-Jun N-terminal kinase and p38 signaling pathways

Acute aortic dissection (AAD) is a life-threating disease; however, there is almost no effective pharmacotherapy for it. An increase in c-Jun N-terminal kinase (JNK) phosphorylation and smooth muscle cell (SMC) apoptosis is observed tissues in patients with AAD. Therefore, we hypothesized that an ac...

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Bibliographic Details
Main Authors: Satoyasu Ito, Kentaro Ozawa, Jing Zhao, Yoji Kyotani, Kosuke Nagayama, Masanori Yoshizumi
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Stretch
c-Jun N-terminal kinase
p38
Acute aortic dissection
Olmesartan
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861314000085

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