The Gut Microbiota and Autism Spectrum Disorders
Gastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut mic...
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doaj-ed8b8802b091404d939e8ca2a64be8842020-11-25T00:45:17ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022017-04-011110.3389/fncel.2017.00120244313The Gut Microbiota and Autism Spectrum DisordersYing Han0Qinrui Li1Angel Belle C. Dy2Randi J. Hagerman3Randi J. Hagerman4Department of Pediatrics, Peking University First HospitalBeijing, ChinaDepartment of Pediatrics, Peking University First HospitalBeijing, ChinaSchool of Medicine and Public Health, Ateneo de Manila UniversityQuezon City, PhilippinesMIND Institute, University of California Davis Medical CenterSacramento, CA, USADepartment of Pediatrics, University of California Davis Medical CenterSacramento, CA, USAGastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut microbiota influences brain development and behaviors through the neuroendocrine, neuroimmune and autonomic nervous systems. In addition, an abnormal gut microbiota is associated with several diseases, such as inflammatory bowel disease (IBD), ASD and mood disorders. Here, we review the bidirectional interactions between the central nervous system and the gastrointestinal tract (brain-gut axis) and the role of the gut microbiota in the central nervous system (CNS) and ASD. Microbiome-mediated therapies might be a safe and effective treatment for ASD.http://journal.frontiersin.org/article/10.3389/fncel.2017.00120/fullautism spectrum disorder (ASD)gut microbiotabrain-gut axisprobioticsfecal microbiota transplantation (FMT) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Han Qinrui Li Angel Belle C. Dy Randi J. Hagerman Randi J. Hagerman |
spellingShingle |
Ying Han Qinrui Li Angel Belle C. Dy Randi J. Hagerman Randi J. Hagerman The Gut Microbiota and Autism Spectrum Disorders Frontiers in Cellular Neuroscience autism spectrum disorder (ASD) gut microbiota brain-gut axis probiotics fecal microbiota transplantation (FMT) |
author_facet |
Ying Han Qinrui Li Angel Belle C. Dy Randi J. Hagerman Randi J. Hagerman |
author_sort |
Ying Han |
title |
The Gut Microbiota and Autism Spectrum Disorders |
title_short |
The Gut Microbiota and Autism Spectrum Disorders |
title_full |
The Gut Microbiota and Autism Spectrum Disorders |
title_fullStr |
The Gut Microbiota and Autism Spectrum Disorders |
title_full_unstemmed |
The Gut Microbiota and Autism Spectrum Disorders |
title_sort |
gut microbiota and autism spectrum disorders |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2017-04-01 |
description |
Gastrointestinal (GI) symptoms are a common comorbidity in patients with autism spectrum disorder (ASD), but the underlying mechanisms are unknown. Many studies have shown alterations in the composition of the fecal flora and metabolic products of the gut microbiome in patients with ASD. The gut microbiota influences brain development and behaviors through the neuroendocrine, neuroimmune and autonomic nervous systems. In addition, an abnormal gut microbiota is associated with several diseases, such as inflammatory bowel disease (IBD), ASD and mood disorders. Here, we review the bidirectional interactions between the central nervous system and the gastrointestinal tract (brain-gut axis) and the role of the gut microbiota in the central nervous system (CNS) and ASD. Microbiome-mediated therapies might be a safe and effective treatment for ASD. |
topic |
autism spectrum disorder (ASD) gut microbiota brain-gut axis probiotics fecal microbiota transplantation (FMT) |
url |
http://journal.frontiersin.org/article/10.3389/fncel.2017.00120/full |
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