GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24859-2 |
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doaj-ed8c3b2903a54147ade49ed6c779e8e52021-08-15T11:39:20ZengNature Publishing GroupNature Communications2041-17232021-08-0112111310.1038/s41467-021-24859-2GOT1 inhibition promotes pancreatic cancer cell death by ferroptosisDaniel M. Kremer0Barbara S. Nelson1Lin Lin2Emily L. Yarosz3Christopher J. Halbrook4Samuel A. Kerk5Peter Sajjakulnukit6Amy Myers7Galloway Thurston8Sean W. Hou9Eileen S. Carpenter10Anthony C. Andren11Zeribe C. Nwosu12Nicholas Cusmano13Stephanie Wisner14Nneka E. Mbah15Mengrou Shan16Nupur K. Das17Brian Magnuson18Andrew C. Little19Milan R. Savani20Johanna Ramos21Tina Gao22Stephen A. Sastra23Carmine F. Palermo24Michael A. Badgley25Li Zhang26John M. Asara27Samuel K. McBrayer28Marina Pasca di Magliano29Howard C. Crawford30Yatrik M. Shah31Kenneth P. Olive32Costas A. Lyssiotis33Department of Molecular & Integrative Physiology, University of MichiganGraduate Program in Cancer Biology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganImmunology Graduate Program, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganGraduate Program in Cancer Biology, University of MichiganGraduate Program in Cancer Biology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Biostatistics, School of Public Health, University of MichiganRogel Cancer Center, University of MichiganMedical Scientist Training Program, University of Texas Southwestern Medical CenterDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical CenterDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical CenterDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical CenterDepartment of Molecular & Integrative Physiology, University of MichiganDivision of Signal Transduction and Mass Spectrometry Core, Beth Israel Deaconess Medical CenterChildren’s Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical CenterRogel Cancer Center, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical CenterDepartment of Molecular & Integrative Physiology, University of MichiganThe aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.https://doi.org/10.1038/s41467-021-24859-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Daniel M. Kremer Barbara S. Nelson Lin Lin Emily L. Yarosz Christopher J. Halbrook Samuel A. Kerk Peter Sajjakulnukit Amy Myers Galloway Thurston Sean W. Hou Eileen S. Carpenter Anthony C. Andren Zeribe C. Nwosu Nicholas Cusmano Stephanie Wisner Nneka E. Mbah Mengrou Shan Nupur K. Das Brian Magnuson Andrew C. Little Milan R. Savani Johanna Ramos Tina Gao Stephen A. Sastra Carmine F. Palermo Michael A. Badgley Li Zhang John M. Asara Samuel K. McBrayer Marina Pasca di Magliano Howard C. Crawford Yatrik M. Shah Kenneth P. Olive Costas A. Lyssiotis |
| spellingShingle |
Daniel M. Kremer Barbara S. Nelson Lin Lin Emily L. Yarosz Christopher J. Halbrook Samuel A. Kerk Peter Sajjakulnukit Amy Myers Galloway Thurston Sean W. Hou Eileen S. Carpenter Anthony C. Andren Zeribe C. Nwosu Nicholas Cusmano Stephanie Wisner Nneka E. Mbah Mengrou Shan Nupur K. Das Brian Magnuson Andrew C. Little Milan R. Savani Johanna Ramos Tina Gao Stephen A. Sastra Carmine F. Palermo Michael A. Badgley Li Zhang John M. Asara Samuel K. McBrayer Marina Pasca di Magliano Howard C. Crawford Yatrik M. Shah Kenneth P. Olive Costas A. Lyssiotis GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis Nature Communications |
| author_facet |
Daniel M. Kremer Barbara S. Nelson Lin Lin Emily L. Yarosz Christopher J. Halbrook Samuel A. Kerk Peter Sajjakulnukit Amy Myers Galloway Thurston Sean W. Hou Eileen S. Carpenter Anthony C. Andren Zeribe C. Nwosu Nicholas Cusmano Stephanie Wisner Nneka E. Mbah Mengrou Shan Nupur K. Das Brian Magnuson Andrew C. Little Milan R. Savani Johanna Ramos Tina Gao Stephen A. Sastra Carmine F. Palermo Michael A. Badgley Li Zhang John M. Asara Samuel K. McBrayer Marina Pasca di Magliano Howard C. Crawford Yatrik M. Shah Kenneth P. Olive Costas A. Lyssiotis |
| author_sort |
Daniel M. Kremer |
| title |
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis |
| title_short |
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis |
| title_full |
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis |
| title_fullStr |
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis |
| title_full_unstemmed |
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis |
| title_sort |
got1 inhibition promotes pancreatic cancer cell death by ferroptosis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis. |
| url |
https://doi.org/10.1038/s41467-021-24859-2 |
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