GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
Main Authors: | Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive, Costas A. Lyssiotis |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-24859-2 |
Similar Items
-
Defining the Mechanism of Methuosis, a Non-apoptotic Cell Death Pathway, Induced by Indolyl Chalcone Compounds in Glioblastoma Cells
by: Mbah, Nneka Elizabeth
Published: (2016) -
Information Management System for Electronic Voting in support of the Schieffelin Award for Excellence in Teaching
by: Magliano, Samuel A.
Published: (2012) -
Cyst fluid metabolites distinguish malignant from benign pancreatic cysts
by: Jiaqi Shi, et al.
Published: (2021-11-01) -
Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm
by: Heather K. Schofield, et al.
Published: (2018-01-01) -
Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer
by: Wenting Du, et al.
Published: (2021-07-01)