Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer
Abstract Background Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate of [18F]PSMA-1007-PET/CT in patients with biochemically recurrent PCa...
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doaj-ed8ec9e45ecf44c9b2078faeac5a5ed22021-05-02T11:23:46ZengSpringerOpenEJNMMI Research2191-219X2021-04-0111111010.1186/s13550-021-00783-wParameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancerNiloefar Ahmadi Bidakhvidi0Annouschka Laenen1Sander Jentjens2Christophe M. Deroose3Koen Van Laere4Liesbeth De Wever5Cindy Mai6Charlien Berghen7Gert De Meerleer8Karin Haustermans9Steven Joniau10Wouter Everaerts11Karolien Goffin12Department of Nuclear Medicine, University Hospitals LeuvenInteruniversity Institute for Biostatistics and Statistical BioinformaticsDepartment of Nuclear Medicine, University Hospitals LeuvenDepartment of Nuclear Medicine, University Hospitals LeuvenDepartment of Nuclear Medicine, University Hospitals LeuvenDepartment of Radiology, University Hospitals LeuvenDepartment of Radiology, University Hospitals LeuvenDepartment of Radiation Oncology, University Hospitals LeuvenDepartment of Radiation Oncology, University Hospitals LeuvenDepartment of Radiation Oncology, University Hospitals LeuvenDepartment of Urology, University Hospitals LeuvenDepartment of Urology, University Hospitals LeuvenDepartment of Nuclear Medicine, University Hospitals LeuvenAbstract Background Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate of [18F]PSMA-1007-PET/CT in patients with biochemically recurrent PCa and identify parameters that predict scan positivity as well as the type and number of detected lesions. This monocentric retrospective study included 137 PCa patients with biochemical recurrence who underwent one or more [18F]PSMA-1007-PET/CT scans between August 2018 and June 2019. PET-positive malignant lesions were classified as local recurrence, lymph node (LN), bone or soft tissue lesions. The association between biochemical/paraclinical parameters, as PSA value, PSA doubling time, PSA velocity, Gleason score (GS) and androgen deprivation therapy (ADT), and scan positivity as well as type and number of detected lesions was evaluated using logistic regression analysis (binary outcomes) and Poisson models (count-type outcomes). Results We included 175 [18F]PSMA-1007-PET/CT scans after radical prostatectomy (78%), external beam radiation therapy (8.8%), ADT (7.3%), brachytherapy (5.1%) and high intensity focused ultrasound (0.7%) as primary treatment (median PSA value 1.6 ng/ml). Positivity rate was 80%. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence of bone and soft tissue lesions and number of bone, LN and soft tissue lesions, both in uni- and/or multivariable analysis. Multivariable analysis also showed prior ADT as predictor of bone and soft tissue lesions, GS as predictor of the number of bone lesions and ongoing ADT as predictor of the number of LN lesions. Conclusion [18F]PSMA-1007-PET/CT showed a high positivity rate in patients with biochemically recurrent PCa. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence and number of bone and soft tissue lesions and the number of LN lesions. Our findings can guide clinicians in optimal patient selection for [18F]PSMA-1007-PET/CT and support further research leading to the development of a prediction nomogram.https://doi.org/10.1186/s13550-021-00783-w[18F]PSMA-1007-PET/CTBiochemical recurrenceLesion-typeProstate cancerPSA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Niloefar Ahmadi Bidakhvidi Annouschka Laenen Sander Jentjens Christophe M. Deroose Koen Van Laere Liesbeth De Wever Cindy Mai Charlien Berghen Gert De Meerleer Karin Haustermans Steven Joniau Wouter Everaerts Karolien Goffin |
spellingShingle |
Niloefar Ahmadi Bidakhvidi Annouschka Laenen Sander Jentjens Christophe M. Deroose Koen Van Laere Liesbeth De Wever Cindy Mai Charlien Berghen Gert De Meerleer Karin Haustermans Steven Joniau Wouter Everaerts Karolien Goffin Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer EJNMMI Research [18F]PSMA-1007-PET/CT Biochemical recurrence Lesion-type Prostate cancer PSA |
author_facet |
Niloefar Ahmadi Bidakhvidi Annouschka Laenen Sander Jentjens Christophe M. Deroose Koen Van Laere Liesbeth De Wever Cindy Mai Charlien Berghen Gert De Meerleer Karin Haustermans Steven Joniau Wouter Everaerts Karolien Goffin |
author_sort |
Niloefar Ahmadi Bidakhvidi |
title |
Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer |
title_short |
Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer |
title_full |
Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer |
title_fullStr |
Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer |
title_full_unstemmed |
Parameters predicting [18F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer |
title_sort |
parameters predicting [18f]psma-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2021-04-01 |
description |
Abstract Background Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate of [18F]PSMA-1007-PET/CT in patients with biochemically recurrent PCa and identify parameters that predict scan positivity as well as the type and number of detected lesions. This monocentric retrospective study included 137 PCa patients with biochemical recurrence who underwent one or more [18F]PSMA-1007-PET/CT scans between August 2018 and June 2019. PET-positive malignant lesions were classified as local recurrence, lymph node (LN), bone or soft tissue lesions. The association between biochemical/paraclinical parameters, as PSA value, PSA doubling time, PSA velocity, Gleason score (GS) and androgen deprivation therapy (ADT), and scan positivity as well as type and number of detected lesions was evaluated using logistic regression analysis (binary outcomes) and Poisson models (count-type outcomes). Results We included 175 [18F]PSMA-1007-PET/CT scans after radical prostatectomy (78%), external beam radiation therapy (8.8%), ADT (7.3%), brachytherapy (5.1%) and high intensity focused ultrasound (0.7%) as primary treatment (median PSA value 1.6 ng/ml). Positivity rate was 80%. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence of bone and soft tissue lesions and number of bone, LN and soft tissue lesions, both in uni- and/or multivariable analysis. Multivariable analysis also showed prior ADT as predictor of bone and soft tissue lesions, GS as predictor of the number of bone lesions and ongoing ADT as predictor of the number of LN lesions. Conclusion [18F]PSMA-1007-PET/CT showed a high positivity rate in patients with biochemically recurrent PCa. PSA value and PSA velocity were significant predictors of scan positivity as well as of the presence and number of bone and soft tissue lesions and the number of LN lesions. Our findings can guide clinicians in optimal patient selection for [18F]PSMA-1007-PET/CT and support further research leading to the development of a prediction nomogram. |
topic |
[18F]PSMA-1007-PET/CT Biochemical recurrence Lesion-type Prostate cancer PSA |
url |
https://doi.org/10.1186/s13550-021-00783-w |
work_keys_str_mv |
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