Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that results from the loss of upper and lower motor neurons. One of the key pathological hallmarks in diseased neurons is the mislocalization of disease-associated proteins and the formation of cytoplasmic aggregates of these protei...
Main Authors: | Nandini Ramesh, Udai Bhan Pandey |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-08-01
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Series: | Frontiers in Molecular Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00263/full |
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