The evolving role of genetic tests in reproductive medicine
Abstract Infertility is considered a major public health issue, and approximately 1 out of 6 people worldwide suffer from infertility during their reproductive lifespans. Thanks to technological advances, genetic tests are becoming increasingly relevant in reproductive medicine. More genetic tests a...
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2019-08-01
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Online Access: | http://link.springer.com/article/10.1186/s12967-019-2019-8 |
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doaj-ed9226bb3a144c1fbe4e8f1c9067e9962020-11-25T03:39:13ZengBMCJournal of Translational Medicine1479-58762019-08-0117113310.1186/s12967-019-2019-8The evolving role of genetic tests in reproductive medicineFederica Cariati0Valeria D’Argenio1Rossella Tomaiuolo2KronosDNA srl, Spinoff of Università Federico IIKronosDNA srl, Spinoff of Università Federico IIKronosDNA srl, Spinoff of Università Federico IIAbstract Infertility is considered a major public health issue, and approximately 1 out of 6 people worldwide suffer from infertility during their reproductive lifespans. Thanks to technological advances, genetic tests are becoming increasingly relevant in reproductive medicine. More genetic tests are required to identify the cause of male and/or female infertility, identify carriers of inherited diseases and plan antenatal testing. Furthermore, genetic tests provide direction toward the most appropriate assisted reproductive techniques. Nevertheless, the use of molecular analysis in this field is still fragmented and cumbersome. The aim of this review is to highlight the conditions in which a genetic evaluation (counselling and testing) plays a role in improving the reproductive outcomes of infertile couples. We conducted a review of the literature, and starting from the observation of specific signs and symptoms, we describe the available molecular tests. To conceive a child, both partners' reproductive systems need to function in a precisely choreographed manner. Hence to treat infertility, it is key to assess both partners. Our results highlight the increasing importance of molecular testing in reproductive medicine.http://link.springer.com/article/10.1186/s12967-019-2019-8Genetic testsReproductive medicineMale infertilityFemale infertilityAssisted reproductive technology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Federica Cariati Valeria D’Argenio Rossella Tomaiuolo |
spellingShingle |
Federica Cariati Valeria D’Argenio Rossella Tomaiuolo The evolving role of genetic tests in reproductive medicine Journal of Translational Medicine Genetic tests Reproductive medicine Male infertility Female infertility Assisted reproductive technology |
author_facet |
Federica Cariati Valeria D’Argenio Rossella Tomaiuolo |
author_sort |
Federica Cariati |
title |
The evolving role of genetic tests in reproductive medicine |
title_short |
The evolving role of genetic tests in reproductive medicine |
title_full |
The evolving role of genetic tests in reproductive medicine |
title_fullStr |
The evolving role of genetic tests in reproductive medicine |
title_full_unstemmed |
The evolving role of genetic tests in reproductive medicine |
title_sort |
evolving role of genetic tests in reproductive medicine |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2019-08-01 |
description |
Abstract Infertility is considered a major public health issue, and approximately 1 out of 6 people worldwide suffer from infertility during their reproductive lifespans. Thanks to technological advances, genetic tests are becoming increasingly relevant in reproductive medicine. More genetic tests are required to identify the cause of male and/or female infertility, identify carriers of inherited diseases and plan antenatal testing. Furthermore, genetic tests provide direction toward the most appropriate assisted reproductive techniques. Nevertheless, the use of molecular analysis in this field is still fragmented and cumbersome. The aim of this review is to highlight the conditions in which a genetic evaluation (counselling and testing) plays a role in improving the reproductive outcomes of infertile couples. We conducted a review of the literature, and starting from the observation of specific signs and symptoms, we describe the available molecular tests. To conceive a child, both partners' reproductive systems need to function in a precisely choreographed manner. Hence to treat infertility, it is key to assess both partners. Our results highlight the increasing importance of molecular testing in reproductive medicine. |
topic |
Genetic tests Reproductive medicine Male infertility Female infertility Assisted reproductive technology |
url |
http://link.springer.com/article/10.1186/s12967-019-2019-8 |
work_keys_str_mv |
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